CuBr-Catalyzed Oxidative Difluoromethylation of Tertiary Amines with Difluoroenol Silyl Ethers

被引：112

作者：

Chu, Lingling ^{[1
]}

Zhang, Xingang ^{[1
]}

Qing, Feng-Ling ^{[1
,2
]}

机构：

[1] Chinese Acad Sci, Key Lab Organofluorine Chem, Shanghai Inst Organ Chem, Shanghai 200032, Peoples R China

[2] Donghua Univ, Coll Chem Chem Engn & Biotechnol, Shanghai 201620, Peoples R China

来源：

ORGANIC LETTERS | 2009年 / 11卷 / 10期

基金：

中国国家自然科学基金;

关键词：

SP(3) C-H; CONVENIENT SYNTHETIC ACCESS; MOLECULAR-OXYGEN; HYDROGEN-PEROXIDE; MANNICH REACTION; BONDS ADJACENT; BETA-PEPTIDE; ACIDS; ACTIVATION; CYANATION;

D O I：

10.1021/ol900541n

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

CuBr-catalyzed oxidative difluoromethylation of readily available tertiary amines with difluoroenol silyl ethers was performed under mild conditions to afford beta-amine-alpha,alpha-difluoro ketones.

引用

页码：2197 / 2200

页数：4

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