Protein folding: Thickening the broth

被引：50

作者：

Minton, AP ^{[1
]}

机构：

[1] NIH, Bethesda, MD 20892 USA

来源：

CURRENT BIOLOGY | 2000年 / 10卷 / 03期

关键词：

D O I：

10.1016/S0960-9822(00)00301-8

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Recent results support the notion that macromolecular 'crowding' enhances protein aggregation, at the expense of correct folding. The results can be rationalised in terms of kinetic competition between distinct processes, taking into account the relative influence of crowding on each process.

引用

页码：R97 / R99

页数：3

共 15 条

[11] THE FOLDING OF HEN LYSOZYME INVOLVES PARTIALLY STRUCTURED INTERMEDIATES AND MULTIPLE PATHWAYS [J].