Zn(salen)-catalyzed asymmetric alkynylation of ketones

被引：55

作者：

Saito, B ^{[1
]}

Katsuki, T ^{[1
]}

机构：

[1] Kyushu Univ, Fac Sci, Grad Sch, Dept Chem,Higashi Ku, Fukuoka 8128581, Japan

来源：

SYNLETT | 2004年 / 09期

关键词：

Zn(salen) complex; asymmetric catalysis; asymmetric alkynylation; ketone; tertiary propargylic alcohol;

D O I：

10.1055/s-2004-829057

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

An in situ generated Zn complex of salen ligand 4 was found to serve as an efficient catalyst for asymmetric addition reaction of an alkynylzinc reagent to various ketones. For example, addition of phenylacetylene to 3,3-dimethyl-2-butanone using the Zn complex as catalyst showed enantioselectivity as high as 91 % ee.

引用

页码：1557 / 1560

页数：4

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