The question of DNA repair in hyperthermophilic archaea

被引:74
作者
Grogan, DW [1 ]
机构
[1] Univ Cincinnati, Dept Biol Sci, Cincinnati, OH 45221 USA
基金
美国国家科学基金会;
关键词
D O I
10.1016/S0966-842X(00)01729-7
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
Hyperthermophilic archaea grow at temperatures that destabilize the primary structure of DNA and in evolutionary terms ley are highly divergent from other well studied microorganisms. These prokaryotes should therefore require DNA damage repair to be unusually effective, and could employ novel mechanisms for this repair, Recent genome sequence analyses and biochemical and genetic assays suggest a distribution of DNA repair strategies that raises intriguing questions for future study.
引用
收藏
页码:180 / 185
页数:6
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