Leukemia Propagating Cells Rebuild an Evolving Niche in Response to Therapy

被引：202

作者：

Duan, Cai-Wen ^{[1
,2
]}

Shi, Jun ^{[3
]}

Chen, Jing ^{[4
,5
]}

Wang, Bo ^{[1
,2
]}

Yu, Ye-Hua ^{[3
]}

Qin, Xia ^{[4
,5
]}

Zhou, Xiang-Cheng ^{[1
,2
]}

Cai, Yi-Jun ^{[1
,2
]}

Li, Zuo-Qing ^{[1
,2
]}

Zhang, Fang ^{[4
,5
]}

Yin, Min-Zhi ^{[4
,5
]}

Tao, Ying ^{[3
]}

Mi, Jian-Qing ^{[6
]}

Li, Lin-Heng ^{[7
]}

Enver, Tariq ^{[8
]}

Chen, Guo-Qiang ^{[1
,2
]}

Hong, Deng-Li ^{[1
,2
]}

机构：

[1] Shanghai Jiao Tong Univ, Sch Med, Key Lab Cell Differentiat & Apoptosis, Natl Minist Educ,Dept Pathophysiol, Shanghai 200025, Peoples R China

[2] Shanghai Jiao Tong Univ, Sch Med, Ruijin Hosp, Shanghai 200025, Peoples R China

[3] SJTU SM, People Hosp 6, Dept Hematol, Shanghai 200233, Peoples R China

[4] SJTU SM, Dept Hematol Oncol, Key Lab Pediat Hematol & Oncol, Minist Hlth, Shanghai 200127, Peoples R China

[5] SJTU SM, Shanghai Childrens Med Ctr, Dept Pathol, Shanghai 200127, Peoples R China

[6] SJTU SM, Shanghai Inst Hematol, Ruijin Hosp, Shanghai 200025, Peoples R China

[7] Stowers Inst Med Res, Kansas City, MO 64110 USA

[8] UCL, UCL Canc Inst, Stem Cell Lab, London WC1E 6BT, England

来源：

CANCER CELL | 2014年 / 25卷 / 06期

基金：

中国国家自然科学基金;

关键词：

MESENCHYMAL STEM-CELLS; ACUTE LYMPHOBLASTIC-LEUKEMIA; ACUTE MYELOGENOUS LEUKEMIA; BONE-MARROW NICHE; HEMATOPOIETIC-STEM; CHEMOTHERAPY; EVOLUTION; FIBROSIS; ALPHA; TIME;

D O I：

10.1016/j.ccr.2014.04.015

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 [肿瘤学];

摘要：

Residence of cancer-propagating cells (CPCs) within preferential microenvironmental niches has a major part in evading therapy. However, the nature of niches involved and the mechanisms protecting CPCs remain largely unknown. We addressed these issues in mouse transplantation models of acute lymphoblastic leukemia (ALL). When the engrafted leukemic cells substantially damaged adjacent microenvironment in the bone marrow (BM), after chemotherapy small foci of CPCs were retained, surrounded by sheaths of supporting cells that comprise a protective niche. We investigated patients' BM biopsies and found evidence of a similar process in patients receiving induction therapy. The efficacy of chemotherapy was enhanced by interfering with the niche formation or function. We therefore identified a therapy-induced niche that protects CPCs.

引用

页码：778 / 793

页数：16

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