Multidentate Block-Copolymer-Stabilized Ultrasmall Superparamagnetic Iron Oxide Nanoparticles with Enhanced Colloidal Stability for Magnetic Resonance Imaging

被引:61
作者
Chan, Nicky [1 ,2 ]
Laprise-Pelletier, Myriam [3 ,4 ]
Chevallier, Pascale [3 ,4 ]
Bianchi, Andrea [5 ]
Fortin, Marc-Andre [3 ,4 ,6 ]
Oh, Jung Kwon [1 ,2 ,6 ]
机构
[1] Concordia Univ, Dept Chem & Biochem, Montreal, PQ H4B 1R6, Canada
[2] Concordia Univ, Ctr Nanosci Res, Montreal, PQ H4B 1R6, Canada
[3] Ctr Hosp Univ Quebec CR CHUQ, Ctr Rech, Quebec City, PQ G1L 3L5, Canada
[4] Univ Laval, Dept Min Met & Mat Engn, Ctr Rech Mat Avances CERMA, Quebec City, PQ G1V 0A6, Canada
[5] Univ Montreal, Dept Phys, Montreal, PQ H3T 1J4, Canada
[6] Univ Laval, CQMF, Quebec City, PQ, Canada
基金
加拿大自然科学与工程研究理事会;
关键词
TRANSFER RADICAL POLYMERIZATION; SIZE-CONTROLLED SYNTHESIS; IN-VIVO TRACKING; CONTRAST AGENTS; CANCER; NANOCRYSTALS; FUNCTIONALIZATION; MICROSPHERES; PEGYLATION; DESIGN;
D O I
10.1021/bm500311k
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
070307 [化学生物学]; 071010 [生物化学与分子生物学];
摘要
Ultrasmall superparamagnetic iron oxide nanoparticles (USPIOs) with diameters <5 nm hold great promise as T-1-positive contrast agents for in vivo magnetic resonance imaging. However, control of the surface chemistry of USPIOs to ensure individual colloidal USPIOs with a ligand monolayer and to impart biocompatibility and enhanced colloidal stability is essential for successful clinical applications. Herein, an effective and versatile strategy enabling the development of aqueous colloidal USPIOs stabilized with well-defined multidentate block copolymers (MDBCs) is reported. The multifunctional MDBCs are designed to consist of an anchoring block possessing pendant carboxylates as multidentate anchoring groups strongly bound to USPIO surfaces and a hydrophilic block having pendant hydrophilic oligo(ethylene oxide) chains to confer water dispersibility and biocompatibility. The surface of USPIOs is saturated with multiple anchoring groups of MDBCs, thus exhibiting excellent long-term colloidal stability as well as enhanced colloidal stability at biologically relevant electrolyte, pH, and temperature conditions. Furthermore, relaxometric properties as well as in vitro and in vivo MR imaging results demonstrate that the MDBC-stabilized USPIO colloids hold great potential as an effective T-1 contrast agent.
引用
收藏
页码:2146 / 2156
页数:11
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