Human IRGM induces autophagy to eliminate intracellular mycobacteria

被引：715

作者：

Singh, Sudha B.

Davis, Alexander S.

Taylor, Gregory A.

Deretic, Vojo ^{[1
]}

机构：

[1] Univ New Mexico, Sch Med, Dept Mol Genet & Microbiol, Albuquerque, NM 87131 USA

[2] Univ New Mexico, Sch Med, Dept Cell Biol & Physiol, Albuquerque, NM 87131 USA

[3] Duke Univ, Dept Med, Durham, NC 27710 USA

[4] Duke Univ, Dept Microbiol & Mol Genet, Durham, NC 27710 USA

[5] Duke Univ, Dept Immunol, Durham, NC 27710 USA

[6] Duke Univ, Ctr Study Aging, Durham, NC 27710 USA

[7] Dept Vet Affairs Med Ctr, Ctr Geriatr Res Educ & Clin, Durham, NC 27710 USA

来源：

SCIENCE | 2006年 / 313卷 / 5792期

关键词：

D O I：

10.1126/science.1129577

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Immunity-related p47 guanosine triphosphatases (IRG) play a role in defense against intracellular pathogens. We found that the murine Irgm1 (LRG-47) guanosine triphosphatase induced autophagy and generated large autolysosomal organelles as a mechanism for the elimination of intracellular Mycobacterium tuberculosis. We also identified a function for a human IRG protein in the control of intracellular pathogens and report that the human Irgm1 ortholog, IRGM, plays a role in autophagy and in the reduction of intracellular bacillary load.

引用

页码：1438 / 1441

页数：4

共 23 条

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