A free ligand for the asymmetric dihydroxylation of olefins utilizing one-phase catalysis and two-phase separation

被引：31

作者：

Kuang, YQ ^{[1
]}

Zhang, SY ^{[1
]}

Jiang, R ^{[1
]}

Wei, LL ^{[1
]}

机构：

[1] Fourth Mil Med Univ, Dept Chem, Xian 710032, Peoples R China

来源：

TETRAHEDRON LETTERS | 2002年 / 43卷 / 20期

基金：

中国国家自然科学基金;

关键词：

asymmetric dihydroxylation; cinchona alkaloid derivative; homogeneous catalysis; osmium catalyst;

D O I：

10.1016/S0040-4039(02)00624-X

中图分类号：

O62 [有机化学];

学科分类号：

070303 [有机化学]; 081704 [应用化学];

摘要：

A free cinchona alkaloid derivative, which can be recovered and reused in the same way as the reported soluble polymer-supported cinchona alkaloid-derived ligands, was applied to the homogeneous asymmetric dihydroxylation of olefins. The molar ratio of ligand/olefin was 5%, being much lower than that required for the corresponding soluble polymer-supported ligands (10-25%). Yields of 82-93% and ees of 89-99% have been obtained. (C) 2002 Elsevier Science Ltd. All rights reserved.

引用

页码：3669 / 3671

页数：3

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