Hebbian mechanisms revealed by electrical stimulation at developing rat neuromuscular junctions

被引:59
作者
Busetto, G [1 ]
Buffelli, M [1 ]
Tognana, E [1 ]
Bellico, F [1 ]
Cangiano, A [1 ]
机构
[1] Univ Verona, Sez Fisiol Umana, Dipartimento Sci Neurol & Vis, I-37134 Verona, Italy
关键词
synapse elimination; synchronous activity; synaptic competition; neuromuscular junction; polyneuronal innervation; chronic conduction block; chronic nerve electrical stimulation; development of neural connections;
D O I
10.1523/JNEUROSCI.20-02-00685.2000
中图分类号
Q189 [神经科学];
学科分类号
071006 ;
摘要
Synapse competition and elimination are widespread developmental processes, first demonstrated at neonatal neuromuscular junctions. Action potential activity was long shown to exert a powerful influence, but mechanisms and contribution relative to other factors are still not well understood. Here we show that replacement of natural motoneuronal discharge with synchronous activity suppresses elimination of polyneuronal innervation of myofibers. This requires the simultaneous chronic conduction block (tetrodotoxin) and distal electrical stimulation of motor axons during ectopic synaptogenesis in denervated adult soleus muscle. If in fact chronic stimulation is applied without central block of motor axons, the time course of synapse elimination is as fast as in control muscles undergoing natural activity. Our findings follow the prediction of Hebb's postulate and imply that asynchronous activity drives developmental synapse elimination in muscle. They further suggest that motoneurons could become transiently synchronized during development and regeneration, helping to establish the initial polyneuronal innervation.
引用
收藏
页码:685 / 695
页数:11
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