The life of lipid droplets

被引:376
作者
Walther, Tobias C. [1 ]
Farese, Robert V., Jr. [2 ,3 ,4 ]
机构
[1] Max Planck Inst Biochem, D-82152 Martinsried, Germany
[2] Gladstone Inst Cardiovasc Dis, San Francisco, CA USA
[3] Univ Calif San Francisco, Dept Med & Biochem, San Francisco, CA 94143 USA
[4] Univ Calif San Francisco, Dept Biophys, San Francisco, CA 94143 USA
来源
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS | 2009年 / 1791卷 / 06期
关键词
Adiposome; Triglyceride; Steryl ester; Fat storage; Organelle dynamic; DIFFERENTIATION-RELATED PROTEIN; HUMAN APOLIPOPROTEIN-E; VIRUS CORE PROTEIN; ENDOPLASMIC-RETICULUM; DIACYLGLYCEROL ACYLTRANSFERASE; ACYL-COA; SACCHAROMYCES-CEREVISIAE; ALPHA-SYNUCLEIN; BINDING DOMAIN; PERILIPIN-A;
D O I
10.1016/j.bbalip.2008.10.009
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
Lipid droplets are the least characterized of cellular organelles. Long considered simple lipid storage depots, these dynamic and remarkable organelles have recently been implicated in many biological processes, and we are only now beginning to gain insights into their fascinating lives in cells. Here we examine what we know of the life of lipid droplets. We review emerging data concerning their cellular biology and present our thoughts on some of the most salient questions for investigation. (C) 2008 Elsevier B.V. All rights reserved.
引用
收藏
页码:459 / 466
页数:8
相关论文
共 86 条
[1]   PLD1 and ERK2 regulate cytosolic lipid droplet formation [J].
Andersson, Linda ;
Bostrom, Pontus ;
Ericson, Johanna ;
Rutberg, Mikael ;
Magnusson, Bjorn ;
Marchesan, Denis ;
Ruiz, Michel ;
Asp, Lennart ;
Huang, Ping ;
Frohman, Michael A. ;
Boren, Jan ;
Olofsson, Sven-Olof .
JOURNAL OF CELL SCIENCE, 2006, 119 (11) :2246-2257
[2]   Lipidomics reveals that adiposomes store ether lipids and mediate phospholipid traffic [J].
Bartz, Rene ;
Li, Wen-Hong ;
Venables, Barney ;
Zehmer, John K. ;
Roth, Mary R. ;
Welti, Ruth ;
Anderson, Richard G. W. ;
Liu, Pingsheng ;
Chapman, Kent D. .
JOURNAL OF LIPID RESEARCH, 2007, 48 (04) :837-847
[3]   Dynamic activity of lipid droplets: Protein phosphorylation and GTP-Mediated protein translocation [J].
Bartzt, Rene ;
Zehmer, John K. ;
Zhu, Meifang ;
Chen, Yue ;
Serrero, Ginette ;
Zhao, Yingming ;
Liu, Pingsheng .
JOURNAL OF PROTEOME RESEARCH, 2007, 6 (08) :3256-3265
[4]   Characterization of the Drosophila lipid droplet subproteome [J].
Beller, Mathias ;
Riedel, Dietmar ;
Jaensch, Lothar ;
Dieterich, Guido ;
Wehland, Juergen ;
Jaeckle, Herbert ;
Kuehnlein, Ronald P. .
MOLECULAR & CELLULAR PROTEOMICS, 2006, 5 (06) :1082-1094
[5]   An intimate collaboration between peroxisomes and lipid bodies [J].
Binns, Derk ;
Januszewski, Tom ;
Chen, Yue ;
Hill, Justin ;
Markin, Vladislav S. ;
Zhao, Yingming ;
Gilpin, Christopher ;
Chapman, Kent D. ;
Anderson, Richard G. W. ;
Goodman, Joel M. .
JOURNAL OF CELL BIOLOGY, 2006, 173 (05) :719-731
[6]  
BLANCHETTEMACKIE EJ, 1995, J LIPID RES, V36, P1211
[7]   Cytosolic lipid droplets increase in size by microtubule-dependent complex formation [J].
Boström, P ;
Rutberg, M ;
Ericsson, J ;
Holmdahl, P ;
Andersson, L ;
Frohman, MA ;
Borén, J ;
Olofsson, SO .
ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY, 2005, 25 (09) :1945-1951
[8]   SNARE proteins mediate fusion between cytosolic lipid droplets and are implicated in insulin sensitivity [J].
Bostrom, Pontus ;
Andersson, Linda ;
Rutberg, Mikael ;
Perman, Jeanna ;
Lidberg, Ulf ;
Johansson, Bengt R. ;
Fernandez-Rodriguez, Julia ;
Ericson, Johanna ;
Nilsson, Tommy ;
Boren, Jan ;
Olofsson, Sven-Olof .
NATURE CELL BIOLOGY, 2007, 9 (11) :1286-U139
[9]   Proteomic analysis of proteins associated with lipid droplets of basal and lipolytically stimulated 3T3-L1 adipocytes [J].
Brasaemle, DL ;
Dolios, G ;
Shapiro, L ;
Wang, R .
JOURNAL OF BIOLOGICAL CHEMISTRY, 2004, 279 (45) :46835-46842
[10]   Glycolipid transfer proteins [J].
Brown, Rhoderick E. ;
Mattjus, Peter .
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS, 2007, 1771 (06) :746-760