Dihydropyridines bearing an imidazo[2,1-b]thiazole system

被引：8

作者：

Andreani, A ^{[1
]}

Leoni, A ^{[1
]}

Rambaldi, M ^{[1
]}

Locatelli, A ^{[1
]}

Bossa, R ^{[1
]}

Galatulas, I ^{[1
]}

Chiericozzi, M ^{[1
]}

Bissoli, M ^{[1
]}

机构：

[1] UNIV MILAN,CTM,DIPARTIMENTO FARMACOL,I-20129 MILAN,ITALY

来源：

EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY | 1997年 / 32卷 / 02期

关键词：

imidazo[2,1-b]thiazole; dihydropyridine; nifedipine; verapamil; antiarrhythmic activity; inotropic activity; chronotropic activity;

D O I：

10.1016/S0223-5234(97)87542-3

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

This paper reports the synthesis of imidazo[2,1-b]thiazoles, bearing a dihydropyridine ring at the 5 or 6 position, which were tested for antiarrhythmic, inotropic and chronotropic activities. Nine of the ten compounds bearing double bond at the 2,3 position and the same dihydropyridine as nifedipine at the 5 position, were antiarrhythmic; moreover one of them (bearing a methyl group at the 2 position) was devoid of negative inotropic activity.

引用

页码：151 / 157

页数：7

共 34 条

[1]

ANDREANI A, 1986, EUR J MED CHEM, V21, P55

[2] POTENTIAL ANTI-TUMOR AGENTS .7. 5-SUBSTITUTED 6-PHENYLIMIDAZO[2,1-B]THIAZOLES [J].