Epidemiology, demographic characteristics and prognostic predictors of ulcerative colitis

被引:344
作者
da Silva, Bruno Cesar [1 ]
Lyra, Andre Castro [2 ,3 ]
Rocha, Raquel [4 ]
Santana, Genoile Oliveira [2 ]
机构
[1] Univ Fed Bahia, Postgrad Program Med & Hlth, BR-40110060 Salvador, BA, Brazil
[2] Univ Fed Bahia, Univ Hosp Prof Edgard Santos, Dept Gastroenterol, BR-40110060 Salvador, BA, Brazil
[3] Hosp Sao Rafael, Gastro Hepatol Serv, BR-40110060 Salvador, BA, Brazil
[4] Univ Fed Bahia, Sch Nutr, Dept Nutr Sci, BR-40110150 Salvador, BA, Brazil
关键词
Ulcerative colitis; Incidence; Prevalence; Risk factors; Predictive factors; INFLAMMATORY-BOWEL-DISEASE; PRIMARY SCLEROSING CHOLANGITIS; CAUSE-SPECIFIC MORTALITY; ANTINEUTROPHIL CYTOPLASMIC ANTIBODIES; POPULATION-BASED COHORT; CROHNS-DISEASE; FECAL CALPROTECTIN; COLORECTAL-CANCER; NATURAL-HISTORY; CLINICAL-COURSE;
D O I
10.3748/wjg.v20.i28.9458
中图分类号
R57 [消化系及腹部疾病];
学科分类号
100201 [内科学];
摘要
Ulcerative colitis (UC) is a chronic disease characterized by diffuse inflammation of the mucosa of the colon and rectum. The hallmark clinical symptom of UC is bloody diarrhea. The clinical course is marked by exacerbations and remissions, which may occur spontaneously or in response to treatment changes or intercurrent illnesses. UC is most commonly diagnosed in late adolescence or early adulthood, but it can occur at any age. The incidence of UC has increased worldwide over recent decades, especially in developing nations. In contrast, during this period, therapeutic advances have improved the life expectancy of patients, and there has been a decrease in the mortality rate over time. It is important to emphasize that there is considerable variability in the phenotypic presentation of UC. Within this context, certain clinical and demographic characteristics are useful in identifying patients who tend to have more severe evolution of the disease and a poor prognosis. In this group of patients, better clinical surveillance and more intensive therapy may change the natural course of the disease. The aim of this article was to review the epidemiology and demographic characteristics of UC and the factors that may be associated with its clinical prognosis. (C) 2014 Baishideng Publishing Group Inc. All rights reserved.
引用
收藏
页码:9458 / 9467
页数:10
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