学术探索
学术期刊
新闻热点
数据分析
智能评审

Phospholipase A2 enzymes:: structural diversity in lipid messenger metabolism

被引：26
作者：
Dessen, A [1 ]
机构：
[1] European Mol Biol Lab, F-38000 Grenoble, France
来源：
STRUCTURE WITH FOLDING & DESIGN | 2000年 / 8卷 / 02期
关键词：
D O I：
10.1016/S0969-2126(00)00097-6
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
The:phospholipases A(2) (PLA(2)s) are a large family of enzymes: with varied lipidic products which are involved in numerous signal transduction pathways, The structural and:functional characterization of several PLA(2)s have revealed the various mechanisms used by these enzymes to ingeniously manipulate the phospholipidic metabolic machinery.
引用
收藏
页码：R15 / R22
页数：8
相关论文
共 65 条
  • [1] INHIBITION OF MACROPHAGE CA2+-INDEPENDENT PHOSPHOLIPASE A(2) BY BROMOENOL LACTONE AND TRIFLUOROMETHYL KETONES
    ACKERMANN, EJ
    CONDEFRIEBOES, K
    DENNIS, EA
    [J]. JOURNAL OF BIOLOGICAL CHEMISTRY, 1995, 270 (01) : 445 - 450
  • [2] BALBOA MA, 1997, J CELL BIOL, V272, P8676
  • [3] Regulation and inhibition of phospholipase A2
    Balsinde, J
    Balboa, MA
    Insel, PA
    Dennis, EA
    [J]. ANNUAL REVIEW OF PHARMACOLOGY AND TOXICOLOGY, 1999, 39 : 175 - 189
  • [4] Function and inhibition of intracellular calcium-independent phospholipase A(2)
    Balsinde, J
    Dennis, EA
    [J]. JOURNAL OF BIOLOGICAL CHEMISTRY, 1997, 272 (26) : 16069 - 16072
  • [5] Reduced fertility and postischaemic brain injury in mice deficient in cytosolic phospholipase A(2)
    Bonventre, JV
    Huang, ZH
    Taheri, MR
    OLeary, E
    Li, E
    Moskowitz, MA
    Sapirstein, A
    [J]. NATURE, 1997, 390 (6660) : 622 - 625
  • [6] A NOVEL ARACHIDONIC ACID-SELECTIVE CYTOSOLIC PLA2 CONTAINS A CA2+-DEPENDENT TRANSLOCATION DOMAIN WITH HOMOLOGY TO PKC AND GAP
    CLARK, JD
    LIN, LL
    KRIZ, RW
    RAMESHA, CS
    SULTZMAN, LA
    LIN, AY
    MILONA, N
    KNOPF, JL
    [J]. CELL, 1991, 65 (06) : 1043 - 1051
  • [7] DENNIS EA, 1994, J BIOL CHEM, V269, P13057
  • [8] The growing phospholipase A(2) superfamily of signal transduction enzymes
    Dennis, EA
    [J]. TRENDS IN BIOCHEMICAL SCIENCES, 1997, 22 (01) : 1 - 2
  • [9] A TWIST IN THE TALE OF LIPOLYTIC ENZYMES
    DEREWENDA, ZS
    [J]. NATURE STRUCTURAL BIOLOGY, 1995, 2 (05): : 347 - 349
  • [10] Crystal structure of human cytosolic phospholipase A2 reveals a novel topology and catalytic mechanism
    Dessen, A
    Tang, J
    Schmidt, H
    Stahl, M
    Clark, JD
    Seehra, J
    Somers, WS
    [J]. CELL, 1999, 97 (03) : 349 - 360
1234567