Phospholipase A2 enzymes:: structural diversity in lipid messenger metabolism

被引:26
作者
Dessen, A [1 ]
机构
[1] European Mol Biol Lab, F-38000 Grenoble, France
来源
STRUCTURE WITH FOLDING & DESIGN | 2000年 / 8卷 / 02期
关键词
D O I
10.1016/S0969-2126(00)00097-6
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
The:phospholipases A(2) (PLA(2)s) are a large family of enzymes: with varied lipidic products which are involved in numerous signal transduction pathways, The structural and:functional characterization of several PLA(2)s have revealed the various mechanisms used by these enzymes to ingeniously manipulate the phospholipidic metabolic machinery.
引用
收藏
页码:R15 / R22
页数:8
相关论文
共 65 条
  • [31] Regulatory functions of phospholipase A(2)
    Murakami, M
    Nakatani, Y
    Atsumi, G
    Inoue, K
    Kudo, I
    [J]. CRITICAL REVIEWS IN IMMUNOLOGY, 1997, 17 (3-4) : 225 - 283
  • [32] Location of the membrane-docking face on the Ca2+-activated C2 domain of cytosolic phospholipase A2
    Nalefski, EA
    Falke, JJ
    [J]. BIOCHEMISTRY, 1998, 37 (51) : 17642 - 17650
  • [33] NALEFSKI EA, 1994, J BIOL CHEM, V269, P18239
  • [34] IDENTIFICATION OF THE BINDING DOMAIN FOR SECRETORY PHOSPHOLIPASES A(2) ON THEIR M-TYPE 180-KDA MEMBRANE-RECEPTOR
    NICOLAS, JP
    LAMBEAU, G
    LAZDUNSKI, M
    [J]. JOURNAL OF BIOLOGICAL CHEMISTRY, 1995, 270 (48) : 28869 - 28873
  • [35] Localization of structural elements of bee venom phospholipase A(2) involved in N-type receptor binding and neurotoxicity
    Nicolas, JP
    Lin, Y
    Lambeau, G
    Ghomashchi, F
    Lazdunski, M
    Gelb, MH
    [J]. JOURNAL OF BIOLOGICAL CHEMISTRY, 1997, 272 (11) : 7173 - 7181
  • [36] OBYRNE P, 1997, CHEST, V111, P275
  • [37] THE ALPHA/BETA-HYDROLASE FOLD
    OLLIS, DL
    CHEAH, E
    CYGLER, M
    DIJKSTRA, B
    FROLOW, F
    FRANKEN, SM
    HAREL, M
    REMINGTON, SJ
    SILMAN, I
    SCHRAG, J
    SUSSMAN, JL
    VERSCHUEREN, KHG
    GOLDMAN, A
    [J]. PROTEIN ENGINEERING, 1992, 5 (03): : 197 - 211
  • [38] Crystal structure of a calcium-phospholipid binding domain from cytosolic phospholipase A2
    Perisic, O
    Fong, S
    Lynch, DE
    Bycroft, M
    Williams, RL
    [J]. JOURNAL OF BIOLOGICAL CHEMISTRY, 1998, 273 (03) : 1596 - 1604
  • [39] REDISTRIBUTION OF 5-LIPOXYGENASE AND CYTOSOLIC PHOSPHOLIPASE-A2 TO THE NUCLEAR FRACTION UPON MACROPHAGE ACTIVATION
    PETERSGOLDEN, M
    MCNISH, RW
    [J]. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 1993, 196 (01) : 147 - 153
  • [40] Identification of essential residues for the catalytic function of 85-kDa cytosolic phospholipase A(2) - Probing the role of histidine, aspartic acid, cysteine, and arginine
    Pickard, RT
    Chiou, XG
    Strifler, BA
    DeFelippis, MR
    Hyslop, PA
    Tebbe, AL
    Yee, YK
    Reynolds, LJ
    Dennis, EA
    Kramer, RM
    Sharp, JD
    [J]. JOURNAL OF BIOLOGICAL CHEMISTRY, 1996, 271 (32) : 19225 - 19231