A practical synthesis of 3,4-dimethoxy-o-toluic acid

被引：11

作者：

Connolly, TJ ^{[1
]}

Matchett, M ^{[1
]}

McGarry, P ^{[1
]}

Sukhtankar, S ^{[1
]}

Zhu, J ^{[1
]}

机构：

[1] Roche Palo Alto LLC, NCD Chem Serv, Chem Dev, Palo Alto, CA 94304 USA

来源：

ORGANIC PROCESS RESEARCH & DEVELOPMENT | 2004年 / 8卷 / 04期

关键词：

D O I：

10.1021/op049938t

中图分类号：

O69 [应用化学];

学科分类号：

081704 ;

摘要：

A streamlined, telescoped process has been developed for the preparation of 3,4-dimethoxy-o-toluic acid, starting with economical and readily available 2,3-dimethoxybenzaidehyde. Catalytic reduction of the aldehyde functional group generated dimethoxytoluene, which was brominated in situ. The resultant aryl bromide was isolated, converted into a Grignard reagent, and transformed into a carboxylic acid with dry ice. The process was demonstrated on a pilot-plant scale.

引用

页码：624 / 627

页数：4

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