Microbial transformation of Danazol

被引：23

作者：

Choudhary, MI ^{[1
]}

Azizuddin, ^{[1
]}

Atta-Ur-Rahman, ^{[1
]}

机构：

[1] Univ Karachi, Int Ctr Chem Sci, HEJ Res Inst Chem, Karachi 75270, Pakistan

来源：

NATURAL PRODUCT LETTERS | 2002年 / 16卷 / 02期

关键词：

microbial transformation; Danazol; Fusarium lini; Aspergillus niger; Cephalosporium aphidicola; Bacillus cerus;

D O I：

10.1080/10575630290019994

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Danazol (17beta-hydroxy-17alpha-pregna-2,4-dien-20-yno-[2,3-d] isoxazole) (1) on fermentation with Fusarium lini, Aspergillus niger, and Cephalosporium aphidicola yielded 17beta-hydroxy-2-(hydroxymethyl)-17-alpha-pregn-4-en-20-yn-3-one (2) and 17beta-hydroxy-2-(hydroxymethyl)-17alpha-pregna-1,4-dien-20-yn-3-one (3), while the fermentation of 1 with Bacillus cerus yielded compound 2 only.

引用

页码：101 / 106

页数：6

共 5 条

[1]

Atta-ur-Rahman, 1996, SOLVING PROBLEMS NMR

[2]

ATTAURRAHMAN, 1989, ONE 2 DIMENSIONAL NM

[3]

GIACOPELLO S, 1992, Z NATURFORSCH B, V47, P891

[4] A NEW MICROBIOLOGICAL STEROID REACTION [J].

MANSON, AJ ;

SJOGREN, RE ;

RIANO, M .

JOURNAL OF ORGANIC CHEMISTRY, 1965, 30 (01) :307-&

[5] ISOLATION, SYNTHESIS, AND BIOLOGICAL-ACTIVITY OF 5 METABOLITES OF DANAZOL [J].

ROSI, D ;

NEUMANN, HC ;

CHRISTIANSEN, RG ;

SCHANE, HP ;

POTTS, GO .

JOURNAL OF MEDICINAL CHEMISTRY, 1977, 20 (03) :349-352

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