Efficient synthesis of 2-aryl-6-methyl-2,3-dihydro-1H-pyridin-4-ones

被引：19

作者：

Renault, O

Guillon, J

Dallemagne, P

Rault, S

机构：

[1] Ctr Etud & Rech Medicament Normandie, UFR Sci Pharmaceut, F-14032 Caen, France

[2] SYNTHEVAL, F-14032 Caen, France

来源：

TETRAHEDRON LETTERS | 2000年 / 41卷 / 05期

关键词：

D O I：

10.1016/S0040-4039(99)02164-4

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Syntheses of 2-aryl-6-methyl-2,3-dihydra-1H-pyridin-4-ones were achieved starting from corresponding beta-aryl-amino acids. This reaction sequence involved, as a key step, the condensation of an acid chloride with a diketone using SmI3 as catalyst. A final intramolecular cyclization furnished the attempted product. (C) 2000 Elsevier Science Ltd. All rights reserved.

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页码：681 / 683

页数：3

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