Effects of F171 mutations in the 6′-N-acetyltransferase type Ib [AAC(6′)-Ib] enzyme on susceptibility to aminoglycosides

被引：12

作者：

Chavideh, R ^{[1
]}

Sholly, S ^{[1
]}

Panaite, D ^{[1
]}

Tolmasky, ME ^{[1
]}

机构：

[1] Calif State Univ Fullerton, Dept Biol Sci, Sch Nat Sci & Math, Inst Mol Biol & Nutr, Fullerton, CA 92834 USA

来源：

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY | 1999年 / 43卷 / 11期

关键词：

D O I：

10.1128/AAC.43.11.2811

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

Substitutions at position F171 of 6'-N-acetyltransferase type Ib cause variable loss of aminoglycoside resistance, indicating that this residue plays an important role in the structure and/or function of the enzyme.

引用

页码：2811 / 2812

页数：2

共 18 条

[1] Construction and characterization of an OHIO-1 beta-lactamase bearing Met69Ile and Gly238Ser mutations [J].

Bonomo, RA ;

Knox, JR ;

Rudin, SD ;

Shlaes, DM .

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 1997, 41 (09) :1940-1943

[2] DECIPHERING THE MESSAGE IN PROTEIN SEQUENCES - TOLERANCE TO AMINO-ACID SUBSTITUTIONS [J].

BOWIE, JU ;

REIDHAAROLSON, JF ;

LIM, WA ;

SAUER, RT .

SCIENCE, 1990, 247 (4948) :1306-1310

[3] Mutational analysis of receptor binding mediated by the Dr family of Escherichia coli adhesins [J].

Carnoy, C ;

Moseley, SL .

MOLECULAR MICROBIOLOGY, 1997, 23 (02) :365-379

[4] Bacterial resistance to aminoglycoside antibiotics [J].

Davies, J ;

Wright, GD .

TRENDS IN MICROBIOLOGY, 1997, 5 (06) :234-240

[5] THERMOSENSITIVE MUTANTS OF ASPERGILLUS-AWAMORI GLUCOAMYLASE BY RANDOM MUTAGENESIS - INACTIVATION KINETICS AND STRUCTURAL INTERPRETATION [J].

FLORY, N ;

GORMAN, M ;

COUTINHO, PM ;

FORD, C ;

REILLY, PJ .

PROTEIN ENGINEERING, 1994, 7 (08) :1005-1012

[6] RANDOM MUTAGENESIS USED TO PROBE THE STRUCTURE AND FUNCTION OF BACILLUS-STEAROTHERMOPHILUS ALPHA-AMYLASE [J].

HOLM, L ;

KOIVULA, AK ;

LEHTOVAARA, PM ;

HEMMINKI, A ;

KNOWLES, JKC .

PROTEIN ENGINEERING, 1990, 3 (03) :181-191

[7] Solution structure of the catalytic domain of GCN5 histone acetyltransferase bound to coenzyme A [J].

Lin, YX ;

Fletcher, CM ;

Zhou, JX ;

Allis, CD ;

Wagner, G .

NATURE, 1999, 400 (6739) :86-89

[8] GCN5-related histone N-acetyltransferases belong to a diverse superfamily that includes the yeast SPT10 protein [J].

Neuwald, AF ;

Landsman, D .

TRENDS IN BIOCHEMICAL SCIENCES, 1997, 22 (05) :154-155

[9] IDENTIFICATION OF AMINO-ACID SUBSTITUTIONS THAT ALTER THE SUBSTRATE-SPECIFICITY OF TEM-1 BETA-LACTAMASE [J].

PALZKILL, T ;

BOTSTEIN, D .

JOURNAL OF BACTERIOLOGY, 1992, 174 (16) :5237-5243

[10] Characterization of mutants of the 6′-N-acetyltransferase encoded by the multiresistance transposon TN1331:: Effect of Phe171-to-Leu171 and Tyr80-to-Cys80 substitutions [J].

Panaite, DM ;

Tolmasky, ME .

PLASMID, 1998, 39 (02) :123-133

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