Differential stability of the mRNA secondary structures in the frameshift site of various HIV type 1 viruses

被引:11
作者
Chang, SY
Sutthent, R
Auewarakul, P
Apichartpiyakul, C
Essex, M
Lee, TH
机构
[1] Harvard Univ, Sch Publ Hlth, Dept Immunol & Infect Dis, Boston, MA 02115 USA
[2] Mahidol Univ, Siriraj Hosp, Fac Med, Dept Microbiol, Bangkok 10700, Thailand
[3] Chiang Mai Univ, Fac Med, Dept Microbiol, Chiang Mai 50002, Thailand
关键词
D O I
10.1089/088922299309892
中图分类号
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号
100102 ;
摘要
For many retroviruses, one or more ribosomal frameshift events are required for translation of the Gag-Pol precursor protein, which is subsequently processed into the structural and enzymatic proteins found in mature virions. A specific nucleotide motif, the slippery sequence, as well as a downstream mRNA secondary structure are generally believed to have roles in the frameshift event. In HIV-1, a particular stem-loop mRNA secondary structure has been proposed for subtype B, On the basis of this model, HIV-1 subtypes A, E, and F were found in this study to share a similar stem-loop structure predicted to have a lower thermodynamic stability as compared with HIV-1 subtypes B, C, and D, The potential impact of this differential thermodynamic stability on HIV-1 replication remains to be determined.
引用
收藏
页码:1591 / 1596
页数:6
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