The Nrf2-Antioxidant Response Element Signaling Pathway and Its Activation by Oxidative Stress

被引：2331

作者：

Nguyen, Truyen ^{[2
]}

Nioi, Paul ^{[2
]}

Pickett, Cecil B. ^{[1
]}

机构：

[1] Biogen Idec Inc, Cambridge, MA 02142 USA

[2] Schering Plough Res Inst, Summit, NJ 07901 USA

来源：

JOURNAL OF BIOLOGICAL CHEMISTRY | 2009年 / 284卷 / 20期

关键词：

TRANSCRIPTION FACTOR NRF2; PROTEIN-KINASE-C; YA-SUBUNIT GENE; CONTROLLING INDUCIBLE EXPRESSION; SUBSTRATE ADAPTER PROTEIN; CUL3-BASED E3 LIGASE; ANTIOXIDANT RESPONSE; PHOSPHATIDYLINOSITOL; 3-KINASE; PROTEASOMAL DEGRADATION; TERT-BUTYLHYDROQUINONE;

D O I：

10.1074/jbc.R900010200

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

070307 [化学生物学]; 071010 [生物化学与分子生物学];

摘要：

A major mechanism in the cellular defense against oxidative or electrophilic stress is activation of the Nrf2-antioxidant response element signaling pathway, which controls the expression of genes whose protein products are involved in the detoxication and elimination of reactive oxidants and electrophilic agents through conjugative reactions and by enhancing cellular antioxidant capacity. At the molecular level, however, the regulatory mechanisms involved in mediating Nrf2 activation are not fully understood. It is well established that Nrf2 activity is controlled, in part, by the cytosolic protein Keap1, but the nature of this pathway and the mechanisms by which Keap1 acts to repress Nrf2 activity remain to be fully characterized and are the topics of discussion in this minireview. In addition, a possible role of the Nrf2-antioxidant response element transcriptional pathway in neuroprotection will also be discussed.

引用

页码：13291 / 13295

页数：5

共 52 条

[1]

Phosphorylation of Nrf2 at Ser40 by protein kinase C in response to antioxidants leads to the release of Nrf2 from INrf2, but is not required for Nrf2 stabilization/accumulation in the nucleus and transcriptional activation of antioxidant response element-mediated NAD(P)H:quinone oxidoreductase-1 gene expression [J].