A role for Streptococcus pneumoniae in virus-associated pneumonia

被引：421

作者：

Madhi, SA

Klugman, KP ^{[1
]}

机构：

[1] Emory Univ, Univ Witwatersrand Med Res Council Natl Inst Comm, Atlanta, GA 30332 USA

[2] Emory Univ, Rollins Sch Publ Hlth, Dept Int Hlth, Atlanta, GA 30332 USA

[3] Emory Univ, Sch Med, Div Infect Dis, Atlanta, GA 30332 USA

来源：

NATURE MEDICINE | 2004年 / 10卷 / 08期

关键词：

D O I：

10.1038/nm1077

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Here we show, in a double-blind, randomized, placebo-controlled trial in 37,107 fully immunized infants in Soweto, South Africa, that a 9-valent pneumococcal conjugate vaccine, PncCV, prevents 31% (95% confidence interval = 15 - 43%) of pneumonias associated with any of seven respiratory viruses in children in hospital. These data suggest that the pneumococcus has a major role in the development of pneumonia associated with these viruses and that viruses contribute to the pathogenesis of bacterial pneumonia.

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收藏

页码：811 / 813

页数：3

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