More than structural cells, fibroblasts create and orchestrate the tumor microenvironment

被引：85

作者：

Baglole, Carolyn J.

Ray, Denise M.

Bernstein, Steven H.

Feldon, Steven E.

Smith, Terry J.

Sime, Patricia J.

Phipps, Richard P.

机构：

[1] Univ Rochester, Sch Med & Dent, Dept Environm Med, Rochester, NY 14642 USA

[2] Univ Rochester, Sch Med & Dent, Dept Ophthalmol, Rochester, NY 14642 USA

[3] Univ Rochester, Sch Med & Dent, Lung Biol & Dis Program, Rochester, NY 14642 USA

[4] Univ Rochester, Sch Med & Dent, Div Pulm & Crit Care Med, Rochester, NY 14642 USA

[5] James P Wilmot Canc Ctr, Lymphoma Biol Program, Rochester, NY USA

[6] Univ Calif Los Angeles, Harbor Med Ctr, Div Mol Med, Torrance, CA 90509 USA

来源：

IMMUNOLOGICAL INVESTIGATIONS | 2006年 / 35卷 / 3-4期

关键词：

cancer; cyclooxygenase; fibroblast; inflammation; Thy-1;

D O I：

10.1080/08820130600754960

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

The tumor microenvironment comprises many cell types including infiltrating immune cells such as lymphocytes, endothelial cells and a complex stroma consisting mainly of fibroblasts. Fibroblasts are heterogeneous and consist of Thy-1(+) and Thy-1(-) subsets that define different biosynthetic and differentiation potential. They produce mediators linked to carcinogenesis and metastasis, including Cox-2 and PGE(2), both of which are also increased in most cancers. This review will highlight the emerging role of the complex fibroblastic stroma in establishing a microenvironment supporting malignant transformation, tumor growth and attenuation of host anti-tumor immune responses.

引用

页码：297 / 325

页数：29

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[11] In breast carcinoma tissue, immature dendritic cells reside within the tumor, whereas mature dendritic cells are located in peritumoral areas [J].