Efficient and convenient route to (Z)-alpha,beta-unsaturated difluoromethyl ketones based on the reaction of 2,3,3-trifluoro-1-tosyloxy-1-propenyllithium with carbonyl compounds

被引：11

作者：

Funabiki, K ^{[1
]}

Ohtsuki, T ^{[1
]}

Ishihara, T ^{[1
]}

Yamanaka, H ^{[1
]}

机构：

[1] KYOTO INST TECHNOL, DEPT CHEM & MAT TECHNOL, SAKYO KU, KYOTO 606, JAPAN

来源：

CHEMISTRY LETTERS | 1996年 / 01期

关键词：

D O I：

10.1246/cl.1996.5

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

2,3,3-Trifluoro-1-tosyloxy-1-propenyllithium, generated from 2,3,3-trifluoro-1-propenyl p-toluenesulfonate with butyllithium, underwent coupling reaction with various carbonyl compounds to give good yields of 3,4,4-trifluoro-2-tosyloxy-2-butenyl alcohols, whose treatment with concentrated sulfuric acid at room temperature afforded the corresponding (Z)-alpha,beta-unsaturated difluoromethyl ketones in good yields.

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页码：5 / 6

页数：2

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