The mouse is not permissive for equine herpesvirus 2 (EHV-2), however viral DNA persisted in lung and spleen depending on the inoculation route - Brief report

被引：8

作者：

Borchers, K ^{[1
]}

Brackmann, J ^{[1
]}

Kershaw, O ^{[1
]}

机构：

[1] Free Univ Berlin, Inst Virol, Berlin, Germany

来源：

ARCHIVES OF VIROLOGY | 2002年 / 147卷 / 07期

关键词：

D O I：

10.1007/s00705-002-0824-4

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

BALB/c mice were inoculated with 3 EHV-2 low passage isolates. After intranasal inoculation, viral DNA was detected by virus-specific nested PCR in the lung up to day 30 post inoculation and in nasal turbinates till day 7. In trigeminal ganglia, olfactory bulb, brain and lymph nodes viral DNA was randomly shown by PCR. After intraperitoneal inoculation viral DNA was present in lymphoid tissues. The spleen was PCR positive up to day 30 and showed a splenomegaly. Clinical signs, virus replication and viraemia, were not observed and no virus strain-specific differences were obvious. Control mice inoculated with equine herpesvirus 4 were PCR negative in all tissues.

引用

页码：1437 / 1444

页数：8

共 30 条

[21] MOLECULAR CHARACTERIZATION AND DETERMINATION OF THE CODING CAPACITY OF THE GENOME OF EQUINE HERPESVIRUS TYPE-2 BETWEEN THE GENOME COORDINATE-0.235 AND COORDINATED-0.258 (THE ECORI DNA FRAGMENT N-4.2-KBP) [J].