Extracellular factors that regulate neuronal migration in the central nervous system

Neuronal migration is an essential process in the development of the central nervous system (CNS). The movement of neuronal precursors from their birthplaces to their ultimate position in the adult brain is regulated by extrinsic and intrinsic signals. The understanding of the extracellular factors that regulate neuronal migration has increased significantly in the last few years. In this review, we will discuss the latest insights into the roles of the extracellular matrix (ECM), cell adhesion molecules (CAMs), soluble and membrane-bound factors, neurotransmitters and ion channels in the migration of neurons. (C) 2002 ISDN. Published by Elsevier Science Ltd. All rights reserved.