Extracellular factors that regulate neuronal migration in the central nervous system

被引:54
作者
Sobeih, MM
Corfas, G
机构
[1] Childrens Hosp, Dept Neurol, Boston, MA 02115 USA
[2] Childrens Hosp, Div Neurosci, Boston, MA 02115 USA
关键词
radial glia; tangential migration; ganglionic eminence; cerebral cortex; cerebellum; olfactory bulb; rostral migratory stream;
D O I
10.1016/S0736-5748(02)00040-0
中图分类号
Q [生物科学];
学科分类号
07 ; 0710 ; 09 ;
摘要
Neuronal migration is an essential process in the development of the central nervous system (CNS). The movement of neuronal precursors from their birthplaces to their ultimate position in the adult brain is regulated by extrinsic and intrinsic signals. The understanding of the extracellular factors that regulate neuronal migration has increased significantly in the last few years. In this review, we will discuss the latest insights into the roles of the extracellular matrix (ECM), cell adhesion molecules (CAMs), soluble and membrane-bound factors, neurotransmitters and ion channels in the migration of neurons. (C) 2002 ISDN. Published by Elsevier Science Ltd. All rights reserved.
引用
收藏
页码:349 / 357
页数:9
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