Rhomboids: 7 years of a new protease family

被引：35

作者：

Freeman, Matthew ^{[1
]}

机构：

[1] MRC, Mol Biol Lab, Cambridge CB2 0QH, England

来源：

SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY | 2009年 / 20卷 / 02期

关键词：

Rhomboids; Intramembrane protease; EGF receptor; Parasite; Mitochondria; Disease mechanism; INTRAMEMBRANE SERINE PROTEASES; DROSOPHILA EGF RECEPTOR; GROWTH-FACTOR RECEPTOR; DORSAL-VENTRAL AXIS; ALPHA HOMOLOG SPITZ; MITOCHONDRIAL MORPHOLOGY; SIGNALING PATHWAY; SUBSTRATE-SPECIFICITY; PROTEOLYTIC CLEAVAGE; PROVIDENCIA-STUARTII;

D O I：

10.1016/j.semcdb.2008.10.006

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Drosophila Rhomboid-1 was discovered to be the first known intramembrane serine protease about 7 years ago. The study of the rhomboid-like family has since blossomed, and the purpose of this review is to take stock of where the field is, and how it may progress in the next few years. Three major themes are the increasing understanding of the biological roles of rhomboids, the detailed information we now have about their function and mechanism, and the promising leads they offer as medical targets. (C) 2008 Elsevier Ltd. All rights reserved.

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收藏

页码：231 / 239

页数：9

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