The effects of carbamazepine and valproic acid on the erythrocyte glutathione, glutathione peroxidase, superoxide dismutase and serum lipid peroxidation in epileptic children

被引：79

作者：

Cengiz, M ^{[1
]}

Yüksel, A ^{[1
]}

Seven, M ^{[1
]}

机构：

[1] Istanbul Univ Cerrahpasa, Cerrahpasa Med Fac, Dept Med & Biol Sci, Istanbul, Turkey

来源：

PHARMACOLOGICAL RESEARCH | 2000年 / 41卷 / 04期

关键词：

epilepsy; valproate; carbamazepine; antioxidant enzymes;

D O I：

10.1006/phrs.1999.0603

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Some epileptic drugs may change antioxidant enzyme activities in humans and experimental animals. Recent studies suggest that membrane lipid peroxidation may be causally involved in some forms of epilepsy, and the differences are reported in free radical scavenging enzyme levels. GSHpX, SOD, GSH are important parameters of antioxidant defence mechanisms. This study was undertaken to evaluate the effects of valproic acid and carbamazepine (CBZ) therapy on erythrocyte glutathione (GSH), glutathione peroxidase (GSHpX), superoxide dismutase (SOD) and lipid peroxidation. During the treatment with VPA or CBZ, the erythrocyte GSHpX and GSH levels of epileptic children were significantly changed as compared to those of health control subjects. The mean levels of serum lipid peroxidation and erythrocyte superoxide dismutase were not statistically different from controls. The methods used for investigation of glutathione peroxidase, superoxide dismutase, glutathione and serum lipid peroxidation were all based on spectrophotometric measurement. (C) 2000 Academic Press.

引用

页码：423 / 425

页数：3

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