DAMPs and inflammatory processes: the role of redox in the different outcomes

被引：93

作者：

Carta, Sonia ^{[1
]}

Castellani, Patrizia ^{[1
]}

Delfino, Laura ^{[1
]}

Tassi, Sara ^{[1
]}

Vene, Roberta ^{[1
]}

Rubartelli, Anna ^{[1
]}

机构：

[1] Ist Nazl Ric Canc, Cell Biol Unit, I-16132 Genoa, Italy

来源：

JOURNAL OF LEUKOCYTE BIOLOGY | 2009年 / 86卷 / 03期

关键词：

ROS; cysteine; IL-1; beta; B lymphocytes; cancer; oxidative stress; MOLECULAR-PATTERN MOLECULES; CHROMATIN PROTEIN HMGB1; MOBILITY GROUP BOX-1; CELL LUNG-CANCER; NF-KAPPA-B; REACTIVE OXYGEN; OXIDATIVE STRESS; DENDRITIC CELLS; THIOREDOXIN REDUCTASE; LYMPHOCYTE-ACTIVATION;

D O I：

10.1189/jlb.1008598

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Inflammation is deeply entangled with redox modulation. Triggering of PRRs on inflammatory cells induces ROS generation. As a consequence, activated cells mount antioxidant responses to counteract the possible harmful effects of oxidation. Therefore, when repair is completed, homeostasis is restored. Here, we describe some recent results showing that an exuberant antioxidant response to pro-oxidant inflammatory stimuli modifies not only the intra-but also the extracellular redox and contributes to the outcome of the inflammatory process. In particular, the role of redox modulation in IL-1 beta secretion, in B lymphocyte differentiation to plasma cells, and in tumor progression will be discussed, and the potential consequences of extracellular redox alterations on DAMP activity will be considered. J. Leukoc. Biol. 86: 549-555; 2009.

引用

页码：549 / 555

页数：7

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