Physiological responses to the 6-min walk test in patients with chronic obstructive pulmonary disease

被引:188
作者
Troosters, T
Vilaro, J
Rabinovich, R
Casas, A
Barberà, JA
Rodriguez-Roisin, R
Roca, J
机构
[1] Univ Barcelona, Hosp Clin, Servei Pneumol,IDIBAPS, Fac Med,Inst Invest Biomed Agusti Pi & Sunyer, Barcelona 08036, Spain
[2] Katholieke Univ Leuven, Resp Muscle Unit, Fac Phys Educ & Physiotherapy, Leuven, Belgium
[3] Katholieke Univ Leuven, Resp Muscle Unit, Lab Pneumol, Louvain, Belgium
[4] Univ Ramon Llull, EUIF, Barcelona, Spain
关键词
chronic obstructive pulmonary disease; exercise testing; exercise tolerance; 6-min walking test;
D O I
10.1183/09031936.02.02092001
中图分类号
R56 [呼吸系及胸部疾病];
学科分类号
摘要
The 6-min walking test (6MWT) is frequently used to assess functional capacity in chronic cardiopulmonary disorders because of its simplicity. The study examines the physiological responses during encouraged 6MWT in patients with chronic obstructive pulmonary disease. Pulmonary oxygen (O-2) uptake (V'O-2) was measured in 20 mate patients (age 66+/-6 yrs, forced expiratory volume in one second 45+/-14% predicted) during 6MWT and incremental cycling, in random order. O-2 tension in arterial blood, carbon dioxide tension in arterial blood and arterial lactate concentration ([La]-art) were obtained in the last 10 patients. During the 6MWT V'o(2) showed a plateau after the 3rd nun (1.39+/-018, 1.42+/-0.31, and1.40+/-0.30 L(.)min(-1), 4th, 5th and 6th min, respectively), and minute ventilation (V'E) (42+/-8 L(.)min(-1)) was 91% maximal voluntary ventilation. No differences were shown between 6MWT (6th min) and peak cycling exercise in V'O-2 (1.40+/-0.30 versus 1.41+/-0.28 L(.)min(-1), respectively), cardiac frequency (126+/-13 versus 130+/-12 beats(.)min(-1)), or arterial respiratory blood gases. The two tests were significantly different in V'E (42+/-8 versus 47+/-8 L(.)min(-1), 6MWT versus cycling, respectively), carbon dioxide production (1.30+/-0.31 versus 1.45+/-0.18 L(.)min(-1)) and [La]art (2.9+/-1.99 versus 5.9+/-1.51 M). The study demonstrates that an encouraged 6-min walking test generates a high but sustainable oxygen uptake. Since the oxygen uptake plateau reflects the integrated response of the system, it may explain the high prognostic value of the 6-min walking test.
引用
收藏
页码:564 / 569
页数:6
相关论文
共 26 条
[1]  
Baarends E M, 1998, J Cardiopulm Rehabil, V18, P23, DOI 10.1097/00008483-199801000-00003
[2]   IS AN ANTICHOLINERGIC AGENT SUPERIOR TO A BETA(2)-AGONIST IN IMPROVING DYSPNEA AND EXERCISE LIMITATION IN COPD [J].
BLOSSER, SA ;
MAXWELL, SL ;
REEVESHOCHE, MK ;
LOCALIO, AR ;
ZWILLICH, CW .
CHEST, 1995, 108 (03) :730-735
[3]   2-MINUTE, 6-MINUTE, AND 12-MINUTE WALKING TESTS IN RESPIRATORY-DISEASE [J].
BUTLAND, RJA ;
PANG, J ;
GROSS, ER ;
WOODCOCK, AA ;
GEDDES, DM .
BRITISH MEDICAL JOURNAL, 1982, 284 (6329) :1607-1608
[4]   Two-year results after lung volume reduction surgery in α1-antitrypsin deficiency versus smoker's emphysema [J].
Cassina, PC ;
Teschler, H ;
Konietzko, N ;
Theegarten, D ;
Stamatis, G .
EUROPEAN RESPIRATORY JOURNAL, 1998, 12 (05) :1028-1032
[5]  
CELLI BR, 2001, AM J RESP CRIT CARE, V163, pA504
[6]   Cardiorespiratory kinetics during exercises of different muscle groups and mass in old and young [J].
Chilibeck, PD ;
Paterson, DH ;
Smith, WDF ;
Cunningham, DA .
JOURNAL OF APPLIED PHYSIOLOGY, 1996, 81 (03) :1388-1394
[7]   Variability in performance of timed walk tests in pulmonary rehabilitation programs [J].
Elpern, EH ;
Stevens, D ;
Kesten, S .
CHEST, 2000, 118 (01) :98-105
[8]   Supplemental oxygen during pulmonary rehabilitation in patients with COPD with exercise hypoxaemia [J].
Garrod, R ;
Paul, EA ;
Wedzicha, JA .
THORAX, 2000, 55 (07) :539-543
[9]   Peripheral muscle weakness contributes to exercise limitation in COPD [J].
Gosselink, R ;
Troosters, T ;
Decramer, M .
AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE, 1996, 153 (03) :976-980
[10]   TREADMILL WALKING IN OLD-AGE MAY NOT REPRODUCE THE REAL LIFE SITUATION [J].
GREIG, C ;
BUTLER, F ;
SKELTON, D ;
MAHMUD, S ;
YOUNG, A .
JOURNAL OF THE AMERICAN GERIATRICS SOCIETY, 1993, 41 (01) :15-18