Evaluation of the efficacy of Lawsonia alba in the alleviation of carbon tetrachloride-induced oxidative stress

被引：69

作者：

Ahmed, S ^{[1
]}

Rahman, A ^{[1
]}

Alam, A ^{[1
]}

Saleem, M ^{[1
]}

Athar, M ^{[1
]}

Sultana, S ^{[1
]}

机构：

[1] Hamdard Univ, Fac Sci, Dept Med Elementol & Toxicol, New Delhi 110062, India

来源：

JOURNAL OF ETHNOPHARMACOLOGY | 2000年 / 69卷 / 02期

关键词：

Lawsonia alba; hepatoprotective; oxidative stress; carbon tetrachloride; lipid peroxidation;

D O I：

10.1016/S0378-8741(99)00091-4

中图分类号：

Q94 [植物学];

学科分类号：

071001 ;

摘要：

The hepatoprotective activity of the 50% ethanol extract of the bark of Lawsonia alba syn. L. inermis was investigated against the carbon tetrachloride-induced oxidative stress. Pretreatment of rats with doses of 250 and 500 mg/kg of the plant extract significantly (P < 0.001) lowered serum transaminases (GOT and GPT) and LDH levels, respectively, in a dose dependent manner against the significant (P < 0.001) rise of these damage marker enzymes when challenged with CCl4 (1 ml/kg, orally). Parallel to these changes, the plant extract prevented CCl4-induced oxidative stress by significantly maintaining the levels of reduced glutathione (GSH), its metabolizing enzymes and simultaneously inhibiting the production of free radicals. Pretreatment of rats with the extract also inhibited the peroxidation of microsomal lipids in a dose-dependent manner. (C) 2000 Elsevier Science Ireland Ltd. AU rights reserved.

引用

页码：157 / 164

页数：8

共 32 条

[11] SMALLER HALOGENATED ALIPHATIC HYDROCARBONS [J].

CHENOWETH, MB ;

HAKE, CL .

ANNUAL REVIEW OF PHARMACOLOGY AND TOXICOLOGY, 1962, 2 :363-+

[12]

FERREYRA EG, 1974, TOXICOL APPL PHARM, V27, P558

[13]

HABIG WH, 1974, J BIOL CHEM, V249, P7130

[14]

JAIN SK, 1973, MED PLANTS, P91

[15] BROMOBENZENE-INDUCED LIVER NECROSIS - PROTECTIVE ROLE OF GLUTATHIONE AND EVIDENCE FOR 3,4-BROMOBENZENE OXIDE AS HEPATOTOXIC METABOLITE [J].

JOLLOW, DJ ;

MITCHELL, JR ;

ZAMPAGLIONE, N ;

GILLETTE, JR .

PHARMACOLOGY, 1974, 11 (03) :151-169

[16]

KIRTIKAR KR, 1956, INDIAN MED PLANTS, V2, P1077

[17] LACTIC DEHYDROGENASE OF MUSCLE [J].

KORNBERG, A .

METHODS IN ENZYMOLOGY, 1955, 1 :441-443

[18]

Lal JB, 1933, J INDIAN CHEM SOC, V10, P577

[19]

LOWRY OH, 1951, J BIOL CHEM, V193, P265

[20]

MISRA SB, 1979, ACTA BOT INDICA, V7, P147

← 1 2 3 4 →