Alternative splicing of the erythropoietin receptor gene correlates with erythroid differentiation in rat hematopoietic and leukemic cells

被引：9

作者：

Fujita, M

Takahashi, R

Kitada, K

Watanabe, R

Kitazawa, S

Ashoori, F

Liang, P

Saya, H

Serikawa, T

Maeda, S

机构：

[1] KOBE UNIV,SCH MED,DEPT PATHOL 2,CHUO KU,KOBE 650,JAPAN

[2] KYOTO UNIV,GRAD SCH MED,DEPT PATHOL & TUMOR BIOL,SAKYO KU,KYOTO 606,JAPAN

[3] KYOTO UNIV,GRAD SCH MED,INST LAB ANIM,SAKYO KU,KYOTO 606,JAPAN

[4] KUMAMOTO UNIV,SCH MED,DEPT ONCOL,KUMAMOTO 860,JAPAN

来源：

CANCER LETTERS | 1997年 / 112卷 / 01期

关键词：

leukemia; erythropoietin receptor; alternative splicing; differentiation;

D O I：

10.1016/S0304-3835(96)04544-2

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

An alternative splicing of the rat erythropoietin receptor (EpoR) gene was identified in normal and erythroleukemia cells. A 105 bp insert was found at a region corresponding to the extracellular domain ofEpoR. The alternative transcript was translated to a soluble EpoR (EpoR-S) expressed in spleen, bone marrow, and cultured erythroleukemia cells in addition to the full-length EpoR (EpoR-F). One of the rat erythroleukemia sublines, K4DT, which partially lost erythroid phenotypes and manifested monocyte/macrophage characteristics also lacked EpoR-S expression. Thus, expression of EpoR-S may play an important role in differentiation of rat erythroid cells. (C) 1997 Elsevier Science Ireland Ltd.

引用

页码：47 / 55

页数：9

共 28 条

[1] ERYTHROPOIETIN HAS A MITOGENIC AND POSITIVE CHEMOTACTIC EFFECT ON ENDOTHELIAL-CELLS [J].