Dimethylarginines and inflammation markers in patients with chronic kidney disease undergoing dialysis

被引：21

作者：

Oner-Iyidogan, Yildiz ^{[1
]}

Oner, Pernur ^{[2
]}

Kocak, Hikmet ^{[2
]}

Gurdol, Figen ^{[2
]}

Bekpinar, Seldag ^{[2
]}

Unlucerci, Yesim ^{[2
]}

Caliskan, Yasar ^{[3
]}

Cetinalp-Demircan, Pinar ^{[2
]}

Kocak, Taner ^{[4
]}

Turkmen, Aydin ^{[3
]}

机构：

[1] Istanbul Univ, Med Lab Programme, Med Serv Training Sch, Istanbul, Turkey

[2] Istanbul Univ, Dept Biochem, Istanbul Fac Med, TR-34093 Istanbul, Turkey

[3] Istanbul Univ, Dept Nephrol, TR-34093 Istanbul, Turkey

[4] Istanbul Univ, Dept Urol, TR-34093 Istanbul, Turkey

来源：

CLINICAL AND EXPERIMENTAL MEDICINE | 2009年 / 9卷 / 03期

关键词：

ADMA; SDMA; Chronic kidney disease; Inflammation; Dimethylarginines; Dialysis; STAGE RENAL-DISEASE; NITRIC-OXIDE; ASYMMETRIC DIMETHYLARGININE; MAINTENANCE HEMODIALYSIS; OXIDATIVE STRESS; L-ARGININE; METABOLISM; PROTEIN; PLASMA; INHIBITOR;

D O I：

10.1007/s10238-009-0035-3

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

1001 ;

摘要：

The aim of this study was to investigate the pro-oxidant and proinflammatory biomarkers and their relationship with dimethylarginines (DMAs) in patients at various stages of chronic kidney disease (CKD). We studied 114 CKD patients, 36 were hemodialyzed, 41 peritoneal dialyzed and 37 nondialyzed (early stage) CKD patients. The control group consisted of 31 healthy subjects. Plasma levels of asymmetric dimethylarginine (ADMA), symmetric dimethylarginine (SDMA), l-arginine, nitric oxide (NO) and proinflammatory cytokines (TNF-alpha and IL-6) were determined, and their relationships with the degree of disease were evaluated. Both DMAs were at high levels in all CKD patients, whereas arginine concentrations were low in patients undergoing dialysis. Elevated TNF-alpha and IL-6 in CKD patients were indicative of ongoing chronic inflammatory state. A significant positive correlation between SDMA and creatinine suggests that plasma SDMA level may be an index for renal function.

引用

页码：235 / 241

页数：7

共 33 条

[21] Concentration of dimethyl-L-arginine in the plasma of patients with end-stage renal failure [J].

MacAllister, RJ ;

Rambausek, MH ;

Vallance, P ;

Williams, D ;

Hoffmann, KH ;

Ritz, E .

NEPHROLOGY DIALYSIS TRANSPLANTATION, 1996, 11 (12) :2449-2452

[22]

Mak RH, 2007, PERITON DIALYSIS INT, V27, pS298

[23] Guanidino compounds in serum and urine of nondialyzed patients with chronic renal insufficiency [J].

Marescau, B ;

Nagels, G ;

Possemiers, I ;

DeBroe, ME ;

Becaus, I ;

Billiouw, JM ;

Lornoy, W ;

DeDeyn, PP .

METABOLISM-CLINICAL AND EXPERIMENTAL, 1997, 46 (09) :1024-1031

[24] Oxidative stress and haemodialysis:: role of inflammation and duration of dialysis treatment [J].

Nguyen-Khoa, T ;

Massy, ZA ;

De Bandt, JP ;

Kebede, M ;

Salama, L ;

Lambrey, G ;

Witko-Sarsat, V ;

Drüeke, TB ;

Lacour, B ;

Thévenin, M .

NEPHROLOGY DIALYSIS TRANSPLANTATION, 2001, 16 (02) :335-340

[25] Influence of initiation of maintenance hemodialysis on biomarkers of inflammation and oxidative stress [J].

Pupim, LB ;

Himmelfarb, J ;

McMonagle, E ;

Shyr, Y ;

Ikizler, TA .

KIDNEY INTERNATIONAL, 2004, 65 (06) :2371-2379

[26]

Ribeiro ACM, 2001, CARDIOVASC RES, V49, P697, DOI 10.1016/S0008-6363(00)00267-4

[27] LIPOPROTEIN ABNORMALITIES IN HYPERLIPIDEMIC AND NORMOLIPIDEMIC MEN ON HEMODIALYSIS WITH CHRONIC-RENAL-FAILURE [J].

SENTI, M ;

ROMERO, R ;

PEDROBOTET, J ;

PELEGRI, A ;

NOGUES, X ;

RUBIESPRAT, J .

KIDNEY INTERNATIONAL, 1992, 41 (05) :1394-1399

[28] Atherogenic lipoprotein changes in the absence of hyperlipidemia in patients with chronic renal failure treated by hemodialysis [J].

Shoji, T ;

Nishizawa, Y ;

Kawagishi, T ;

Tanaka, M ;

Kawasaki, K ;

Tabata, T ;

Inoue, T ;

Morii, H .

ATHEROSCLEROSIS, 1997, 131 (02) :229-236

[29]

Teerlink T, 2005, METH MOLEC MED, V108, P263

[30]

Thuraisingham RC, 2002, CLIN SCI, V103, P31

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