The monocyte-macrophage axis in the intestine

被引：134

作者：

Bain, Calum C. ^{[1
]}

Mowat, Allan McI ^{[1
]}

机构：

[1] Univ Glasgow, Ctr Immunobiol, Inst Infect Immun & Inflammat, Glasgow G12 8QQ, Lanark, Scotland

来源：

CELLULAR IMMUNOLOGY | 2014年 / 291卷 / 1-2期

基金：

英国惠康基金;

关键词：

Intestine; Macrophages; Monocytes; Homeostasis; Inflammation; INFLAMMATORY-BOWEL-DISEASE; MUCOSAL DENDRITIC CELLS; INNATE IMMUNE DEFENSE; LAMINA-PROPRIA; BLOOD MONOCYTES; CHEMOKINE RECEPTOR; LANGERHANS CELLS; MYELOID CELLS; T-CELLS; MONONUCLEAR PHAGOCYTES;

D O I：

10.1016/j.cellimm.2014.03.012

中图分类号：

Q2 [细胞生物学];

学科分类号：

071013 [干细胞生物学];

摘要：

Macrophages are one of the most abundant leucocytes in the intestinal mucosa where they are essential for maintaining homeostasis. However, they are also implicated in the pathogenesis of disorders such as inflammatory bowel disease (IBD), offering potential targets for novel therapies. Here we discuss the function of intestinal monocytes and macrophages during homeostasis and describe how these populations and their functions change during infection and inflammation. Furthermore, we review the current evidence that the intestinal macrophage pool requires continual renewal from circulating blood monocytes, unlike most other tissue macrophages which appear to derive from primitive precursors that subsequently self-renew. (C) 2014 The Authors. Published by Elsevier Inc.

引用

收藏

页码：41 / 48

页数：8

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