On the TRAIL of obesity and diabetes

被引：56

作者：

Harith, Hanis H. ^{[1
,2
,3
]}

Morris, Margaret J. ^{[2
]}

Kavurma, Mary M. ^{[1
]}

机构：

[1] Univ New S Wales, Sch Med Sci, Ctr Vasc Res, Sydney, NSW 2052, Australia

[2] Univ New S Wales, Sch Med Sci, Sydney, NSW 2052, Australia

[3] Univ Putra Malaysia, Fac Med & Hlth Sci, Dept Biomed Sci, Serdang 43400, Malaysia

来源：

TRENDS IN ENDOCRINOLOGY AND METABOLISM | 2013年 / 24卷 / 11期

关键词：

obesity; diabetes; TRAIL; apoptosis; non-apoptotic signaling; APOPTOSIS-INDUCING-LIGAND; PANCREATIC BETA-CELLS; C-REACTIVE PROTEIN; INSULIN-RESISTANCE; SERUM OSTEOPROTEGERIN; MITOCHONDRIAL DYSFUNCTION; LIPID PARAMETERS; EXPRESSION; DEATH; INFLAMMATION;

D O I：

10.1016/j.tem.2013.07.001

中图分类号：

R5 [内科学];

学科分类号：

100201 [内科学];

摘要：

Tumor necrosis factor (TNF)-related apoptosis-inducing ligand (TRAIL) has been extensively studied for its preferential ability to induce apoptosis of cancer cells. Beyond the cytotoxic capacity of TRAIL, new physiological and pathological roles for TRAIL have been identified, and there is now growing evidence supporting its involvement in the development of obesity and diabetes. This review summarizes the most recent findings associating TRAIL with obesity and diabetes in both humans and experimental settings. We also present and discuss some of the reported controversies behind TRAIL signaling and function. Understanding TRAIL mechanism(s) in vivo and its involvement in disease may lead to novel strategies to combat the growing pandemic of obesity and diabetes worldwide.

引用

页码：578 / 587

页数：10

共 81 条

[1]

Relationship between serum osteoprotegerin, glycemic control, renal function and markers of atherosclerosis in type 2 diabetes [J].

Altinova, Alev E. ;

Toruner, Fusun ;

Akturk, Mujde ;

Bukan, Neslihan ;

Yetkin, Ilhan ;

Cakir, Nuri ;

Arslan, Metin .

SCANDINAVIAN JOURNAL OF CLINICAL & LABORATORY INVESTIGATION, 2011, 71 (04) :340-343

[2]

Expression and regulation of osteoprotegefin in adipose tissue [J].

An, Juan-Ji ;

Han, Dong-He ;

Kim, Dol-Mi ;

Kim, Se-Hwa ;

Rhee, Yurnie ;

Lee, Eun-Jig ;

Lim, Sung-Kil .

YONSEI MEDICAL JOURNAL, 2007, 48 (05) :765-772

[3]

[Anonymous], 2011, National diabetes fact sheet: National estimates and general information on diabetes and prediabetes in the United States

[4]

[Anonymous], 2008, DIAB AUSTR FACTS 200

[5]

Ashley, David T. ;

O'Sullivan, Eoin P. ;

Davenport, Colin ;

Devlin, Niamh ;

Crowley, Rachel K. ;

McCaffrey, Noel ;

Moyna, Niall M. ;

Smith, Diarmuid ;

O'Gorman, Donal J. .

METABOLISM-CLINICAL AND EXPERIMENTAL, 2011, 60 (07) :994-1000

[6]

Augoulea A., 2013, INT J ENDOCRINOL, V2013, P6

[7]

Transcriptional regulation of tumour necrosis factor-related apoptosis-inducing ligand [J].

Azahri, Nor Saadah M. ;

Kavurma, Mary M. .

CELLULAR AND MOLECULAR LIFE SCIENCES, 2013, 70 (19) :3617-3629

[8]

Non-canonical kinase signaling by the death ligand TRAIL in cancer cells: discord in the death receptor family [J].

Azijli, K. ;

Weyhenmeyer, B. ;

Peters, G. J. ;

de Jong, S. ;

Kruyt, F. A. E. .

CELL DEATH AND DIFFERENTIATION, 2013, 20 (07) :858-868

[9]

Bernardi, Stella ;

Zauli, Giorgio ;

Tikellis, Christos ;

Candido, Riccardo ;

Fabris, Bruno ;

Secchiero, Paola ;

Cooper, Mark E. ;

Thomas, Merlin C. .

CLINICAL SCIENCE, 2012, 123 (9-10) :547-555

[10]

Circulating soluble tumor necrosis factor related apoptosis inducing-ligand (TRAIL) is decreased in type-2 newly diagnosed, non-drug using diabetic patients [J].

Bisgin, A. ;

Yalcin, A. D. ;

Gorczynski, R. M. .

DIABETES RESEARCH AND CLINICAL PRACTICE, 2012, 96 (03) :E84-E86

← 1 2 3 4 5 6 7 8 9 →