Neuroprotective and anti-ageing effects of curcumin in aged rat brain regions

被引：149

作者：

Bala, Kiran ^{[1
]}

Tripathy, B. C. ^{[1
]}

Sharma, Deepak ^{[1
]}

机构：

[1] Jawaharlal Nehru Univ, Sch Life Sci, New Delhi 110067, India

来源：

BIOGERONTOLOGY | 2006年 / 7卷 / 02期

关键词：

anti-ageing effects; antioxidant enzymes; curcumin; lipofuscin; Na+K+ stop-ATPase;

D O I：

10.1007/s10522-006-6495-x

中图分类号：

R592 [老年病学]; C [社会科学总论];

学科分类号：

03 ; 0303 ; 100203 ;

摘要：

This study investigated the influence of chronically administered curcumin on normal ageing-related parameters: lipid peroxidation, lipofuscin concentration and intraneuronal lipofuscin accumulation, activities of the enzymes superoxide dismutase (SOD), glutathione peroxidase (GPx), and Na+, K+, -adenosine triphosphatase (Na+, K+, -ATPase) in different brain regions (cerebral cortex, hippocampus, cerebellum and medulla) of 6- and 24-month-old rats. In normal ageing, lipid peroxidation and lipofuscin concentration were found to increase with ageing, the activities of SOD, GPx and Na+, K+, -ATPase, however, decreased with ageing. Chronic curcumin treatment of both 6 and 24 months old rats resulted in significant decreases in lipid peroxide and the lipofuscin contents in brain regions, the activities of SOD, GPx and Na+, K+, -ATPase however, showed significant increase in various brain regions. The present study, thus, demonstrated the antioxidative, antilipofusinogenesic and anti-ageing effects of curcumin in the brain.

引用

页码：81 / 89

页数：9

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