On the antioxidant mechanism of curcumin: Classical methods are needed to determine antioxidant mechanism and activity

被引：271

作者：

Barclay, LRC ^{[1
]}

Vinqvist, MR

Mukai, K

Goto, H

Hashimoto, Y

Tokunaga, A

Uno, H

机构：

[1] Mt Allison Univ, Dept Chem, Sackville, NB E4L 1G8, Canada

[2] Ehime Univ, Ctr Chem Anal, Dept Chem & Adv Instrumentat, Matsuyama, Ehime 7908577, Japan

来源：

ORGANIC LETTERS | 2000年 / 2卷 / 18期

关键词：

D O I：

10.1021/ol000173t

中图分类号：

O62 [有机化学];

学科分类号：

070303 [有机化学]; 081704 [应用化学];

摘要：

The antioxidant activity of curcumin (1,7-bis(4-hydroxy-3-methoxyphenyl)-1,6-heptadiene-3,5-dione) was determined by inhibition of controlled initiation of styrene oxidation, Synthetic nonphenolic curcuminoids exhibited no antioxidant activity; therefore, curcumin is a classical phenolic chain-breaking antioxidant, donating H atoms from the phenolic groups not the CH2 group as has been suggested (Jovanovic et at. J. Am. Chem, Sec. 1999, 121, 9677). The antioxidant activities of omicron-methoxyphenols are decreased in hydrogen bond accepting media.

引用

页码：2841 / 2843

页数：3

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