Smoking as a risk factor for myelodysplastic syndromes and acute myeloid leukemia and its relation to cytogenetic findings: A case-control study

被引：36

作者：

Bjork, Jonas ^{[1
,2
]}

Johansson, Bertil ^{[3
]}

Broberg, Karin ^{[2
]}

Albin, Maria ^{[2
]}

机构：

[1] Lund Univ, Competence Ctr Clin Res, SE-22185 Lund, Sweden

[2] Univ Lund Hosp, Dept Occupat & Environm Med, Lund, Sweden

[3] Univ Lund Hosp, Dept Clin Genet, Lund, Sweden

来源：

LEUKEMIA RESEARCH | 2009年 / 33卷 / 06期

关键词：

Leukemia; Tobacco smoking; Chromosome aberrations; Epidemiology; CIGARETTE-SMOKING; ENVIRONMENTAL EXPOSURES; ABNORMALITIES; ASSOCIATIONS; MORPHOLOGY; SECONDARY;

D O I：

10.1016/j.leukres.2008.10.009

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

In this case-control Study, interview data on smoking habits were available for 179 de novo cases (116 with cytogenetic data) Of acute myeloid leukemia (AML) or myelodysplastic syndromes (MDS). Smoking habits were compared with a pooled set Of Population controls and hospital controls (diagnosed with malignant melanoma). Each pack-year of smoking increased the risk of MDS with 1.3% (95% CI 0.1-2.6%), corresponding to an estimated excess risk of 71% (95% CI 3-180%) for 40 pack-years. Associations between smoking and the specific aberrations -5/5q-, -7/7q-, and +8 in AML and MDS were indicated but the estimates were imprecise. (C) 2008 Elsevier Ltd. All rights reserved.

引用

页码：788 / 791

页数：4

共 28 条

[1] Smoking and acute myeloid leukemia:: associations with morphology and karyotypic patterns and evaluation of dose-response relations [J].

Björk, J ;

Albin, M ;

Mauritzson, N ;

Strömberg, U ;

Johansson, B ;

Hagmar, L .

LEUKEMIA RESEARCH, 2001, 25 (10) :865-872

[2] Smoking and myelodysplastic syndromes [J].

Björk, J ;

Albin, M ;

Mauritzson, N ;

Strömberg, U ;

Johansson, B ;

Hagmar, L .

EPIDEMIOLOGY, 2000, 11 (03) :285-291

[3] CIGARETTE-SMOKING AND ADULT LEUKEMIA - A METAANALYSIS [J].

BROWNSON, RC ;

NOVOTNY, TE ;

PERRY, MC .

ARCHIVES OF INTERNAL MEDICINE, 1993, 153 (04) :469-475

[4] MYELOID LEUKEMIAS AND MYELODYSPLASTIC SYNDROMES - CHEMICAL-EXPOSURE, HISTOLOGIC SUBTYPE AND CYTOGENETICS IN A CASE-CONTROL STUDY [J].

CICCONE, G ;

MIRABELLI, D ;

LEVIS, A ;

GAVAROTTI, P ;

REGECAMBRIN, G ;

DAVICO, L ;

VINEIS, P .

CANCER GENETICS AND CYTOGENETICS, 1993, 68 (02) :135-139

[5]

CRANE MM, 1991, CANCER, V67, P2211, DOI 10.1002/1097-0142(19910415)67:8<2211::AID-CNCR2820670835>3.0.CO

[6]

2-4

[7]

Crane MM, 1996, CANCER EPIDEM BIOMAR, V5, P639

[8]

Davico L, 1998, CANCER EPIDEM BIOMAR, V7, P1123

[9] MORTALITY IN RELATION TO SMOKING - 20 YEARS OBSERVATIONS ON MALE BRITISH DOCTORS [J].

DOLL, R ;

PETO, R .

BRITISH MEDICAL JOURNAL, 1976, 2 (6051) :1525-1536

[10] Cancers weakly related to smoking [J].

Doll, R .

BRITISH MEDICAL BULLETIN, 1996, 52 (01) :35-49

← 1 2 3 →