Smoking as a risk factor for myelodysplastic syndromes and acute myeloid leukemia and its relation to cytogenetic findings: A case-control study

被引：36

作者：

Bjork, Jonas ^{[1
,2
]}

Johansson, Bertil ^{[3
]}

Broberg, Karin ^{[2
]}

Albin, Maria ^{[2
]}

机构：

[1] Lund Univ, Competence Ctr Clin Res, SE-22185 Lund, Sweden

[2] Univ Lund Hosp, Dept Occupat & Environm Med, Lund, Sweden

[3] Univ Lund Hosp, Dept Clin Genet, Lund, Sweden

来源：

LEUKEMIA RESEARCH | 2009年 / 33卷 / 06期

关键词：

Leukemia; Tobacco smoking; Chromosome aberrations; Epidemiology; CIGARETTE-SMOKING; ENVIRONMENTAL EXPOSURES; ABNORMALITIES; ASSOCIATIONS; MORPHOLOGY; SECONDARY;

D O I：

10.1016/j.leukres.2008.10.009

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

In this case-control Study, interview data on smoking habits were available for 179 de novo cases (116 with cytogenetic data) Of acute myeloid leukemia (AML) or myelodysplastic syndromes (MDS). Smoking habits were compared with a pooled set Of Population controls and hospital controls (diagnosed with malignant melanoma). Each pack-year of smoking increased the risk of MDS with 1.3% (95% CI 0.1-2.6%), corresponding to an estimated excess risk of 71% (95% CI 3-180%) for 40 pack-years. Associations between smoking and the specific aberrations -5/5q-, -7/7q-, and +8 in AML and MDS were indicated but the estimates were imprecise. (C) 2008 Elsevier Ltd. All rights reserved.

引用

页码：788 / 791

页数：4

共 28 条

[21]

Pedersen-Bjergaard J, 1998, HAEMATOLOGICA, V83, P481

[22] DIFFERENT GENETIC PATHWAYS IN LEUKEMOGENESIS FOR PATIENTS PRESENTING WITH THERAPY-RELATED MYELODYSPLASIA AND THERAPY-RELATED ACUTE MYELOID-LEUKEMIA [J].

PEDERSENBJERGAARD, J ;

PEDERSEN, M ;

ROULSTON, D ;

PHILIP, P .

BLOOD, 1995, 86 (09) :3542-3552

[23] A case-control study of myelodysplastic syndromes in Belgrade (Serbia Montenegro) [J].

Pekmezovic, Tatjana ;

Vukovic, Nada Suvajdzic ;

Kisic, Darija ;

Grgurevic, Anita ;

Bogdanovic, Andrija ;

Gotic, Mirjana ;

Bakrac, Milena ;

Brkic, Nenad .

ANNALS OF HEMATOLOGY, 2006, 85 (08) :514-519

[24] Non-responders to a postal questionnaire on respiratory symptoms and diseases [J].

Rönmark, E ;

Lundqvist, A ;

Lundbäck, B ;

Nyström, L .

EUROPEAN JOURNAL OF EPIDEMIOLOGY, 1999, 15 (03) :293-299

[25] CIGARETTE-SMOKING AND RISK OF ACUTE-LEUKEMIA - ASSOCIATIONS WITH MORPHOLOGY AND CYTOGENETIC ABNORMALITIES IN BONE-MARROW [J].

SANDLER, DP ;

SHORE, DL ;

ANDERSON, JR ;

DAVEY, FR ;

ARTHUR, D ;

MAYER, RJ ;

SILVER, RT ;

WEISS, RB ;

MOORE, JO ;

SCHIFFER, CA ;

WURSTERHILL, DH ;

MCINTYRE, OR ;

BLOOMFIELD, CD .

JOURNAL OF THE NATIONAL CANCER INSTITUTE, 1993, 85 (24) :1994-2003

[26] Risk factors of myelodysplastic syndromes: a case-control study [J].

Strom, SS ;

Gu, Y ;

Gruschkus, SK ;

Pierce, SA ;

Estey, EH .

LEUKEMIA, 2005, 19 (11) :1912-1918

[27] OCCUPATIONAL AND ENVIRONMENTAL EXPOSURES AND MYELODYSPLASIA - A CASE-CONTROL STUDY [J].

WEST, RR ;

STAFFORD, DA ;

FARROW, A ;

JACOBS, A .

LEUKEMIA RESEARCH, 1995, 19 (02) :127-139

[28] Cytogenetic abnormalities in the myelodysplastic syndromes and occupational or environmental exposure [J].

West, RR ;

Stafford, DA ;

White, AD ;

Bowen, DT ;

Padua, RA .

BLOOD, 2000, 95 (06) :2093-2097

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