New piperidine scaffolds via nucleophilic reactivity of (-)-phenyloxazolopiperidine

被引：30

作者：

Poupon, E

François, D

Kunesch, N

Husson, HP

机构：

[1] CNRS, UMR 8638 Associee, Fac Sci Pharmaceut & Biol, Chim Therapeut Lab, F-75256 Paris 06, France

[2] Univ Paris Sud, CNRS, UMR 8076 BioCIS, Ctr Etud Pharmaceut,Lab Pharmacognosie Associe, F-92296 Chatenay Malabry, France

[3] CNRS, UMR 8638 Associee, Fac Sci Pharmaceut & Biol, Lab Pharmacognosie, F-75256 Paris 06, France

[4] Univ Paris 05, F-75256 Paris 06, France

来源：

JOURNAL OF ORGANIC CHEMISTRY | 2004年 / 69卷 / 11期

关键词：

D O I：

10.1021/jo0499524

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The present work illustrates the power of compound 2 as a chiral, nonracemic, and stable 2-piperideine (enamine) equivalent in the rapid and efficient construction of 3-substituted piperidines (carbon-carbon and carbon-sulfur bonds) such as 3-spiropiperidines. This methodology offers a new route to such systems that could compete with previously reported strategies.

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页码：3836 / 3841

页数：6

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