Activin receptor signaling

被引：59

作者：

Abe, Y

Minegishi, T ^{[1
]}

Leung, PCK

机构：

[1] Gunma Univ, Sch Med, Dept Obstet & Gynecol, Gunma 3718511, Japan

[2] Univ British Columbia, Dept Obstet & Gynecol, Vancouver, BC V6H 3V5, Canada

来源：

GROWTH FACTORS | 2004年 / 22卷 / 02期

关键词：

activin; activin receptor; smad; follistatin; inhibin; betaglycan;

D O I：

10.1080/08977190410001704688

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Activin is a member of the TGF-beta superfamily and has various effects on diverse biological systems. Activins initiate their cellular responses by binding to their receptors with intrinsic serine/threonine kinase activity and activation of specific downstream intracellular effectors termed Smad proteins. Smads relay the signal from the cell membrane to the nucleus, where they affect the transcription of target genes. Negative regulation of activin signal occurs at the extracellular, membrane, cytoplasmic and nuclear levels. The presence of many mechanisms for regulation shows its importance to normal physiology. Here, we review the latest advances in activin signal transduction.

引用

页码：105 / 110

页数：6

共 27 条

[21] Follistatin: Essential role for the N-terminal domain in activin binding and neutralization [J].