Lipoic acid, a lead structure for multi-target-directed drugs for neurodegeneration

被引：42

作者：

Bolognesi, Maria L. ^{[1
]}

Minarini, Anna ^{[1
]}

Tumiatti, Vincenzo ^{[1
]}

Melchiorre, Carlo ^{[1
]}

机构：

[1] Univ Bologna, Dept Pharmaceut Sci, Alma Mater Studiorum, I-40126 Bologna, Italy

来源：

MINI-REVIEWS IN MEDICINAL CHEMISTRY | 2006年 / 6卷 / 11期

关键词：

neurodegenerative diseases; lipoic acid; antioxidants; multi-target-directed drugs; reactive oxygen species;

D O I：

10.2174/138955706778742731

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Nowadays, drug discovery based on a single-target-directed strategy seems inappropriate for the treatment of complex diseases that have multiple pathogenic factors. Recent research into new drugs, which are able to hit different targets, highlights the idea that a single molecule could be sufficient to treat multi-factorial diseases. In this review, examples of multi-target-directed compounds derived from lipoic acid are examined.

引用

页码：1269 / 1274

页数：6

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