Ephrin B expression in epithelial ovarian neoplasms correlates with tumor differentiation and angiogenesis

被引:31
作者
Castellvi, Josep
Garcia, Angel
de la Torre, Javier
Hernandez, Javier
Gil, Antonio
Xercavins, Jordi
Ramon y Cajal, Santiago [1 ]
机构
[1] Hosp Gen Valle Hebron, Dept Pathol, Barcelona 08035, Spain
[2] Hosp Gen Valle Hebron, Dept Gynecol Oncol, Barcelona 08035, Spain
关键词
epithelial ovarian tumors; ephrin B; angiogenesis; prognostic factors;
D O I
10.1016/j.humpath.2006.02.021
中图分类号
R36 [病理学];
学科分类号
100104 ;
摘要
Differential gene expression studies are identifying new sets of genes with a role in the classification, differential diagnosis. and prognosis of some human tumors. Ephrin B1, a factor involved in angiogenesis. has been shown to be up-regulated in ovarian carcinomas, making it a potential target for cancer treatment. This study investigates ephrin B expression in ovarian tumors to validate results front gene expression studies and evaluates its significance with a clinical-pathological correlation. Specimens front 112 benign. borderline. and malignant epithelial ovarian tumors were examined. Tissue microarrays were constructed. and ephrin B expression was studied by immunohistochemistry. To correlate ephrin B expression with angiogenesis, CD31 immunostaining was performed to assess microvessel density. Ephrin B was detected in 50% of ovarian tumors: clear cell carcinomas (93%), serous carcinomas (74%), mucinous carcinomas (29%), and endometrioid carcinomas (27%). High-grade carcinomas showed greatest ephrin B expression, whereas benign tumors and low-grade carcinomas were rarely positive. A correlation was found between ephrin B expression and microvessel density, supporting the angiogenic role of this factor in ovarian carcinomas. Ephrin B expression was associated with higher rates of disease recurrence and a decrease in overall survival. A distinctive pattern of ephrin B expression was observed in ovarian tumors: high-grade tumors and clear cell and serous carcinomas show higher expression. correlating with the aggressiveness. On the other hand, ephrin B expression correlated with microvessel density of the tumors. Because Eph receptors and ephrins are targets for new therapeutic inhibitors, this pattern of ephrin B expression should be considered in future clinical studies. (c) 2006 Elsevier Inc. All rights reserved.
引用
收藏
页码:883 / 889
页数:7
相关论文
共 24 条
[21]   Implications of EPHB6, EFNB2, and EFNB3 expressions in human neuroblastoma [J].
Tang, XX ;
Zhao, HQ ;
Robinson, ME ;
Cohen, B ;
Cnaan, A ;
London, W ;
Cohn, SL ;
Cheung, NKV ;
Brodeur, GM ;
Evans, AE ;
Ikegaki, N .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2000, 97 (20) :10936-10941
[22]  
Uyen HD, 2002, J CELL SCI, V115, P3073
[23]   Human osteosarcoma expresses specific ephrin profiles - Implications for tumorigenicity and prognosis [J].
Varelias, A ;
Koblar, SA ;
Cowled, PA ;
Carter, CD ;
Clayer, M .
CANCER, 2002, 95 (04) :862-869
[24]  
Vogt T, 1998, CLIN CANCER RES, V4, P791