Characterization of the rutin-metal complex by electrospray ionization tandem mass spectrometry

被引：36

作者：

Bai, Y ^{[1
]}

Song, FR ^{[1
]}

Chen, ML ^{[1
]}

Xing, JP ^{[1
]}

Liu, ZQ ^{[1
]}

Liu, SY ^{[1
]}

机构：

[1] Chinese Acad Sci, Changchun Inst Appl Chem, Lab New Drug Res & Mass Spectrometry, Changchun 130022, Peoples R China

来源：

ANALYTICAL SCIENCES | 2004年 / 20卷 / 08期

关键词：

D O I：

10.2116/analsci.20.1147

中图分类号：

O65 [分析化学];

学科分类号：

070302 ; 081704 ;

摘要：

According to the strong application background of bioflavonoid and metal-flavonoid complexes, novel electrospray ionization tandem mass spectrometry (ESI-MSn) was applied to investigate the structure and fragmentation mechanism of transition metal-rutin complexes. In the full-scan mass spectra, different stoichiometric ratios of rutin-metal complexes were found. In the reaction between rutin and Cu, four kinds of complexes with four different stoichiometric ratios were produced. In the reaction between rutin and Zn, Mn(II), and Fe(II), only two kind of complexes with stoichiometric ratios of 1:1 and 1:2 occured. In further tandem mass spectrometric experiments of different rutin-metal complexes, product fragments, came from the neutral loss of the external rhamnose and the internal glucose unit, oligosaccharide chain, aglycone, and small organic molecules. According to the MSn data, we proposed a mechanism for all fragments of the rutin-Cu complex A and the structure of two rutin-Cu complexes, C and D.

引用

页码：1147 / 1151

页数：5

共 33 条

[1] Enhancement of antioxidant and anti-inflammatory activities of bioflavonoid rutin by complexation with transition metals [J].