Pathogenesis of fibrosis:: role of TGF-β and CTGF

被引：278

作者：

Ihn, H ^{[1
]}

机构：

[1] Univ Tokyo, Fac Med, Dept Dermatol, Bunkyo Ku, Tokyo 1138655, Japan

来源：

CURRENT OPINION IN RHEUMATOLOGY | 2002年 / 14卷 / 06期

关键词：

D O I：

10.1097/00002281-200211000-00009

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Transforming growth factor (TGF)-beta regulates diverse biologic activities including cell growth, cell death or apoptosis, cell differentiation, and extracellular matrix (ECM) synthesis. TGF-beta is believed to be a key mediator of tissue fibrosis as a consequence of ECM accumulation in pathologic states such as systemic sclerosis. TGF-beta is known to induce the expression of ECM proteins in mesenchymal cells, and to stimulate the production of protease inhibitors that prevent enzymatic breakdown of the ECM. Connective tissue growth factor (CTGF), which is induced by TGF-beta, has been reported to mediate stimulatory actions of TGF-beta ECM synthesis. This review focuses on the possible role of TGF-beta and CTGF in the pathogenesis of fibrosis.

引用

页码：681 / 685

页数：5

共 78 条

[1] Connective tissue growth factor in human liver cirrhosis
Abou-Shady, M
Friess, H
Zimmermann, A
di Mola, FF
Guo, XZ
Baer, HU
Büchler, MW
[J]. LIVER, 2000, 20 (04): : 296 - 304
[2] Attisano Liliana, 1996, Cytokine and Growth Factor Reviews, V7, P327, DOI 10.1016/S1359-6101(96)00042-1
[3] CACHECTIN AND TUMOR-NECROSIS-FACTOR AS 2 SIDES OF THE SAME BIOLOGICAL COIN
BEUTLER, B
CERAMI, A
[J]. NATURE, 1986, 320 (6063) : 584 - 588
[4] TRANSFORMING GROWTH-FACTOR-BETA IN DISEASE - THE DARK SIDE OF TISSUE-REPAIR
BORDER, WA
RUOSLAHTI, E
[J]. JOURNAL OF CLINICAL INVESTIGATION, 1992, 90 (01) : 1 - 7
[5] BORDER WA, 1994, NEW ENGL J MED, V331, P1286
[6] CONNECTIVE-TISSUE GROWTH-FACTOR - A CYSTEINE-RICH MITOGEN SECRETED BY HUMAN VASCULAR ENDOTHELIAL-CELLS IS RELATED TO THE SRC-INDUCED IMMEDIATE EARLY GENE-PRODUCT CEF-10
BRADHAM, DM
IGARASHI, A
POTTER, RL
GROTENDORST, GR
[J]. JOURNAL OF CELL BIOLOGY, 1991, 114 (06) : 1285 - 1294
[7] CTGF expression is induced by TGF-β in cardiac fibroblasts and cardiac myocytes:: a potential role in heart fibrosis
Chen, MM
Lam, A
Abraham, JA
Schreiner, GF
Joly, AH
[J]. JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY, 2000, 32 (10) : 1805 - 1819
[8] Stimulation of type I collagen transcription in human skin fibroblasts by TGF-β:: Involvement of Smad 3
Chen, SJ
Yuan, WH
Mori, Y
Levenson, A
Trojanowska, M
Varga, J
[J]. JOURNAL OF INVESTIGATIVE DERMATOLOGY, 1999, 112 (01) : 49 - 57
[9] Chen SJ, 2000, J CELL PHYSIOL, V183, P381, DOI 10.1002/(SICI)1097-4652(200006)183:3<381::AID-JCP11>3.0.CO
[10] 2-O

← 1 2 3 4 5 6 7 8 →