Pathogenesis of fibrosis:: role of TGF-β and CTGF

被引:278
作者
Ihn, H [1 ]
机构
[1] Univ Tokyo, Fac Med, Dept Dermatol, Bunkyo Ku, Tokyo 1138655, Japan
关键词
D O I
10.1097/00002281-200211000-00009
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
Transforming growth factor (TGF)-beta regulates diverse biologic activities including cell growth, cell death or apoptosis, cell differentiation, and extracellular matrix (ECM) synthesis. TGF-beta is believed to be a key mediator of tissue fibrosis as a consequence of ECM accumulation in pathologic states such as systemic sclerosis. TGF-beta is known to induce the expression of ECM proteins in mesenchymal cells, and to stimulate the production of protease inhibitors that prevent enzymatic breakdown of the ECM. Connective tissue growth factor (CTGF), which is induced by TGF-beta, has been reported to mediate stimulatory actions of TGF-beta ECM synthesis. This review focuses on the possible role of TGF-beta and CTGF in the pathogenesis of fibrosis.
引用
收藏
页码:681 / 685
页数:5
相关论文
共 78 条
  • [31] IL-4 up-regulates the expression of tissue inhibitor of metalloproteinase-2 in dermal fibroblasts via the p38 mitogen-activated protein kinase-dependent pathway
    Ihn, H
    Yamane, K
    Asano, Y
    Kubo, M
    Tamaki, K
    [J]. JOURNAL OF IMMUNOLOGY, 2002, 168 (04) : 1895 - 1902
  • [32] Ihn H, 2001, ARTHRITIS RHEUM, V44, P474, DOI 10.1002/1529-0131(200102)44:2<474::AID-ANR67>3.3.CO
  • [33] 2-R
  • [34] Sp3 is a transcriptional activator of the human alpha 2(I) collagen gene
    Ihn, H
    Trojanowska, M
    [J]. NUCLEIC ACIDS RESEARCH, 1997, 25 (18) : 3712 - 3717
  • [35] Sp1 phosphorylation induced by serum stimulates the human α2 (I) collagen gene expression
    Ihn, H
    Ihn, Y
    Trojanowska, M
    [J]. JOURNAL OF INVESTIGATIVE DERMATOLOGY, 2001, 117 (02) : 301 - 308
  • [36] Competition analysis of the human α2(I) collagen promoter using synthetic oligonucleotides
    Ihn, H
    Tamaki, K
    [J]. JOURNAL OF INVESTIGATIVE DERMATOLOGY, 2000, 114 (05) : 1011 - 1016
  • [37] Oncostatin M stimulates the growth of dermal fibroblasts via a mitogen-activated protein kinase-dependent pathway
    Ihn, H
    Tamaki, K
    [J]. JOURNAL OF IMMUNOLOGY, 2000, 165 (04) : 2149 - 2155
  • [38] Smad6 inhibits signalling by the TGF-beta superfamily
    Imamura, T
    Takase, M
    Nishihara, A
    Oeda, E
    Hanai, J
    Kawabata, M
    Miyazono, K
    [J]. NATURE, 1997, 389 (6651) : 622 - 626
  • [39] INAGAKI Y, 1994, J BIOL CHEM, V269, P14828
  • [40] Interaction between GC box binding factors and smad proteins modulates cell lineage-specific α2(I) collagen gene transcription
    Inagaki, Y
    Nemoto, T
    Nakao, A
    ten Dijke, P
    Kobayashi, K
    Takehara, K
    Greenwel, P
    [J]. JOURNAL OF BIOLOGICAL CHEMISTRY, 2001, 276 (19) : 16573 - 16579