The control of gene expression in melanocytes and melanomas

被引:13
作者
Eisen, TG
机构
[1] Royal Marsden NHS Trust, London SW3 6JJ
关键词
melanoma; transcription; tyrosinase;
D O I
10.1097/00008390-199608000-00001
中图分类号
R73 [肿瘤学];
学科分类号
100214 ;
摘要
Powerful evidence exists that deregulation of cell type-specific gene expression is a major feature of the genesis of several cancers, with many oncogenic proteins known to possess transcription regulation properties. As a consequence of this deregulation, melanomas may ectopically express HLA-DR and also fail to express enzymes required for melanin synthesis, resulting in amelanotic melanoma. Recent work has demonstrated that these phenomena may be accounted for by the expression of a transcription factor called Brn-2, now known to be involved with the development of neural crest-derived tissues. Brn-2 is normally expressed at high levels in melanoblasts and melanomas but only at low levels in normal melanocytes. Brn-2 may act by competing with another transcription factor, mi, necessary for normal melanocyte development.
引用
收藏
页码:277 / 284
页数:8
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