The role of vascular endothelial growth factor in neurogenesis in adult brain

被引：18

作者：

Galvan, Veronica ^{[1
]}

Greenberg, David A. ^{[1
]}

Jin, Kunlin ^{[1
]}

机构：

[1] Buck Inst Age Res, Novato, CA 94945 USA

来源：

MINI-REVIEWS IN MEDICINAL CHEMISTRY | 2006年 / 6卷 / 06期

关键词：

VEGF; VEGF receptor; neural stem cells; brain; neurogenesis; angiogenesis; growth factor; endothelial cells;

D O I：

10.2174/138955706777435742

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

VEGF is a canonical angiogenic factor. In addition, its role as a stimulator of neurogenesis was recently uncovered. Vascular and nervous networks share common molecular mechanisms underlying their morphogenesis. VEGF is likely to regulate both processes during development and in adult organisms.

引用

收藏

页码：667 / 669

页数：3

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共 68 条

[31]

Kuhn HG, 1996, J NEUROSCI, V16, P2027

[32] Multipotent stem/progenitor cells with similar properties arise from two neurogenic regions of adult human brain [J].

Kukekov, VG ;

Laywell, ED ;

Suslov, O ;

Davies, K ;

Scheffler, B ;

Thomas, LB ;

O'Brien, TF ;

Kusakabe, M ;

Steindler, DA .

EXPERIMENTAL NEUROLOGY, 1999, 156 (02) :333-344

[33] Expression of vascular endothelial growth factor (VEGF) and its receptors (Flt-1 and Flk-1) following permanent and transient occlusion of the middle cerebral artery in the rat [J].

Lennmyr, F ;

Ata, KA ;

Funa, K ;

Olsson, Y ;

Terent, A .

JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY, 1998, 57 (09) :874-882

[34] VASCULAR ENDOTHELIAL GROWTH-FACTOR IS A SECRETED ANGIOGENIC MITOGEN [J].

LEUNG, DW ;

CACHIANES, G ;

KUANG, WJ ;

GOEDDEL, DV ;

FERRARA, N .

SCIENCE, 1989, 246 (4935) :1306-1309

[35] Chain migration of neuronal precursors [J].

Lois, C ;

GarciaVerdugo, JM ;

AlvarezBuylla, A .

SCIENCE, 1996, 271 (5251) :978-981

[36] Coordinated interaction of Neurogenesis and angiogenesis in the adult songbird brain [J].

Louissaint, A ;

Rao, S ;

Leventhal, C ;

Goldman, SA .

NEURON, 2002, 34 (06) :945-960

[37] The netrin receptor UNC5B mediates guidance events controlling morphogenesis of the vascular system (Publication with Expression of Concern) [J].

Lu, XW ;

le Noble, F ;

Yuan, L ;

Jiang, QJ ;

de Lafarge, B ;

Sugiyama, D ;

Bréant, C ;

Claes, F ;

De Smet, F ;

Thomas, JL ;

Autiero, M ;

Carmeliet, P ;

Tessier-Lavigne, M ;

Eichmann, A .

NATURE, 2004, 432 (7014) :179-186

[38] Neural stem cell detection, characterization, and age-related changes in the subventricular zone of mice [J].

Maslov, AY ;

Barone, TA ;

Plunkett, RJ ;

Pruitt, SC .

JOURNAL OF NEUROSCIENCE, 2004, 24 (07) :1726-1733

[39] Vascular endothelial growth factor rescues hippocampal neurons from glutamate-induced toxicity: signal transduction cascades [J].

Matsuzaki, H ;

Tamatani, M ;

Yamaguchi, A ;

Namikawa, K ;

Kiyama, H ;

Vitek, MP ;

Mitsuda, N ;

Tohyama, M .

FASEB JOURNAL, 2001, 15 (07) :1218-1220

[40] HYPOXIC INDUCTION OF HUMAN VASCULAR ENDOTHELIAL GROWTH-FACTOR EXPRESSION THROUGH C-SRC ACTIVATION [J].

MUKHOPADHYAY, D ;

TSIOKAS, L ;

ZHOU, XM ;

FOSTER, D ;

BRUGGE, JS ;

SUKHATME, VP .

NATURE, 1995, 375 (6532) :577-581

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