Case histories, magic bullets and the state of drug discovery

被引：32

作者：

Drews, Juergen

机构：

[1] D-82340 Feldafing

来源：

NATURE REVIEWS DRUG DISCOVERY | 2006年 / 5卷 / 08期

关键词：

EXPERIMENTAL AUTOIMMUNE ENCEPHALOMYELITIS; HIV-1; CYCLOOXYGENASES; ENFUVIRTIDE; INHIBITORS; BEVACIZUMAB; CELECOXIB; EFFICACY; THERAPY; KINASES;

D O I：

10.1038/nrd2084

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

The case histories of five modern drugs are taken as a basis for reflection on the state of drug discovery. Two issues intimately associated with drug research are highlighted: the nature of the intellectual process leading to new discoveries; and the possibility that the principle of selective efficacy, which has guided drug research from its beginnings, might need modification, at least in some areas of pharmacotherapy.

引用

页码：635 / 640

页数：6

共 43 条

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