Lateral organization of endocytic machinery in dendritic spines

被引：158

作者：

Rácz, B

Blanpied, TA

Ehlers, MD

Weinberg, RJ

机构：

[1] Duke Univ, Med Ctr, Dept Neurobiol, Durham, NC 27710 USA

[2] Univ N Carolina, Dept Cell & Dev Biol, Chapel Hill, NC 27599 USA

[3] Univ N Carolina, Ctr Neurosci, Chapel Hill, NC 27599 USA

[4] Duke Univ, Med Ctr, Dept Cell Biol, Durham, NC 27710 USA

[5] Duke Univ, Med Ctr, Dept Pharmacol & Canc Biol, Durham, NC 27710 USA

[6] Duke Univ, Med Ctr, Neuroproteom Lab, Durham, NC 27710 USA

来源：

NATURE NEUROSCIENCE | 2004年 / 7卷 / 09期

基金：

美国国家卫生研究院;

关键词：

D O I：

10.1038/nn1303

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Postsynaptic membrane trafficking plays an important role in synaptic plasticity, but the organization of trafficking machinery within dendritic spines is poorly understood. We use immunocytochemical analysis of rat hippocampal neurons to show that proteins mediating endocytosis are systematically arrayed within dendritic spines, tangential to the synapse. Thus, previously unrecognized lateral domains of the spine organize endocytic protein machinery at sites removed from the postsynaptic density.

引用

页码：917 / 918

页数：2

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